α-Adrenergic receptor blockade attenuates pressor response during mental stress in young black adults.
α-Adrenergic receptor blockade attenuates pressor response during mental stress in young black adults.
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DOI：
10.14814/phy2.14642
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发表时间：
2021-01
影响因子：
2.5
通讯作者：
Park J
中科院分区：
文献类型：
--
作者：
Jeong JH;Brown ML;Kapuku G;Harshfield GA;Park J
黑人个体对交感神经刺激表现出增加的血压（BP）反应，这与高血压（HTN）的风险增加有关。我们检验了以下假设：α1肾上腺素能阻滞剂抑制血压正常的年轻黑人成年人在45分钟应激期间和之后的血压反应升高，这可能部分通过抑制血管收缩和减少肾钠潴留介导。采用双盲、随机、交叉研究设计，51名血压正常的黑人成人（31 ± 8岁）接受安慰剂或1 mg/天哌唑嗪治疗1周。在每次治疗的最后一天，在通过竞争性视频游戏任务诱导的45分钟精神应激之前（休息）、期间（应激）和之后（恢复）收集血液动力学测量和尿钠排泄（UNaV）。在应激期间，哌唑嗪组的舒张压和总外周阻力（TPR）显著低于安慰剂组（两者p <0.05）。同样，我们观察到恢复期哌唑嗪组收缩压、舒张压和TPR均低于安慰剂组（两组p <0.05）。哌唑嗪对应激相关UNaV无影响。从静息到恢复期的收缩压变化与两种治疗的TPR变化呈正相关（两种治疗的p <0.05）。总之，哌唑嗪治疗抑制了血压对45分钟精神应激的反应性，并在恢复期内降低了应激后血压，这与血压正常的年轻黑人成年人的TPR降低有关。这些结果表明，在黑人成人中，α1-肾上腺素能受体活性可能通过增加血管收缩而导致血压反应和对长期精神应激的血压恢复延迟。心理应激与高血压的易感性和严重程度有关。已知黑人个体会对各种压力源产生高血流动力学反应。本研究表明，阻断α-肾上腺素能受体活性可改善血压正常的年轻黑人成年人对精神压力的血压反应。
Black individuals exhibit increased blood pressure (BP) responses to sympathetic stimulation that are associated with an increased risk of hypertension (HTN). We tested the hypothesis that α1‐adrenergic blockade inhibits the increased BP response during and after 45‐min stress in young normotensive Black adults, which may be mediated, in part, by dampened vasoconstriction and decreased renal sodium retention. Utilizing a double‐masked randomized, crossover study design, 51 normotensive Black adults (31 ± 8 yr) were treated with either a placebo or 1 mg/day of prazosin for 1 week. On the final day of each treatment, hemodynamic measures and urinary sodium excretion (UNaV) were collected before (Rest), during (Stress) and after (Recovery) 45 min of mental stress induced via a competitive video game task. During the Stress period, diastolic BP and total peripheral resistance (TPR) were significantly lower with prazosin compared to placebo (p < .05 for both). Similarly, we observed lower systolic BP, diastolic BP, and TPR during the Recovery period with prazosin versus placebo (p < .05 for both). There was no effect of prazosin on stress‐associated UNaV. The change in systolic BP from Rest to Recovery was positively associated with the change in TPR with both treatments (p < .05 for both). In summary, prazosin treatment dampened BP reactivity to 45‐min mental stress and lowered post‐stress BP over the recovery period, which was linked to reduce TPR in young normotensive Black adults. These results suggest that α1‐adrenergic receptor activity may contribute to BP responses and delayed BP recovery to prolonged mental stress through increased vasoconstriction in Black adults. Psychological stress contributes to the susceptibility and severity of hypertension. Black individuals are known to elicit hyper‐hemodynamic responsiveness to various stressors. The present study demonstrated that the blockage of alpha‐adrenergic receptor activity improved the blood pressure responses to mental stress in young normotensive Black adults.
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影响因子：
5.7
作者：
Cene, Crystal W.;Roter, Debra;Cooper, Lisa A.
通讯作者：
Cooper, Lisa A.
DOI：
10.1073/pnas.1618167114
发表时间：
2017-08-15
影响因子：
11.1
作者：
Curtis, David S.;Fuller-Rowell, Thomas E.;Ryff, Carol D.
通讯作者：
Ryff, Carol D.
影响因子：
8.3
作者：
GRAHAM, RM;PETTINGER, WA;GANDLER, T
通讯作者：
GANDLER, T
影响因子：
3.2
作者：
Harshfield, GA;Wilson, ME;Treiber, FA
通讯作者：
Treiber, FA
影响因子：
8.3
作者：
KOEPKE, JP;JONES, S;DIBONA, GF
通讯作者：
DIBONA, GF