Glucose ingestion in cystic fibrosis induces severe redox imbalance: A potential role in diabetes.
Glucose ingestion in cystic fibrosis induces severe redox imbalance: A potential role in diabetes.
复制标题
囊性纤维化中的葡萄糖摄入会导致严重的氧化还原失衡：在糖尿病中的潜在作用。
DOI：
10.1016/j.jcf.2020.02.010
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Stecenko,ArleneA
中科院分区：
文献类型：
--
作者：
Hunt,WilliamR;Hansen,JasonM;Stecenko,ArleneA
背景囊性纤维化相关糖尿病（CFRD）是囊性纤维化（CF）最常见的合并症。与没有CF的人相比，CF个体表现出气道和全身氧化。此外，在非CF糖尿病中由高血糖症沉淀的全身氧化已显示导致增强的炎症。我们假设CF和糖尿病的同时存在会导致高血糖诱导的氧化还原失衡到氧化状态。这反过来又会导致促炎细胞因子的产生增加。MethodsSystemic氧化还原平衡和促炎细胞因子在标准口服葡萄糖耐量试验之前和之后在健康对照（HC）和具有葡萄糖稳态谱的CF个体中测量（即正常葡萄糖耐受- NGT，在基础或葡萄糖诱导的炎症标志物水平方面，两组之间没有显著差异。然而，与NGT和HC的CF相比，患有前驱糖尿病和CFRD的CF受试者的基线全身氧化还原电位显著更氧化。在所有CF组（NGT、前驱糖尿病和CFRD）中，摄入葡萄糖后2小时，全身氧化显著恶化，并达到了深刻的程度。所有三个CF组在两小时点的氧化还原失衡水平是相同的，并且与高血糖程度无关。有一个显着的相关性较差的全身氧化和减少胰岛素secrety.ConclusionsThis支持一个新发现的代谢异常CF -葡萄糖诱导的氧化还原失衡的氧化状态。
BackgroundCystic fibrosis related diabetes (CFRD) is the most common co-morbidity associated with cystic fibrosis (CF). Individuals with CF demonstrate airway and systemic oxidation compared to people without CF. Furthermore, systemic oxidation precipitated by hyperglycemia in non-CF diabetes has been shown to lead to enhanced inflammation. We hypothesized that the presence of both CF and diabetes in an individual would result in hyperglycemia-induced redox imbalance to an oxidative state. This in turn would result in enhanced production of pro-inflammatory cytokines.MethodsSystemic redox balance and pro-inflammatory cytokines were measured before and following a standard oral glucose tolerance test in healthy controls (HC) and in CF individuals with a spectrum of glucose homeostasis (i.e. normal glucose tolerant - NGT, prediabetes or frank CFRD).ResultsThere were no significant differences between groups in terms of basal or glucose-induced levels of inflammatory markers. However, baseline systemic redox potential was significantly more oxidized in CF subjects with prediabetes and CFRD compared to both CF with NGT and HC. Systemic oxidation was significantly worsened, and to a profound degree, two hours following ingestion of glucose in all CF groups (NGT, prediabetes, and CFRD). The level of redox imbalance at the two hour point was the same in all three CF groups and was not associated with the degree of hyperglycemia. There was a significant correlation between worse systemic oxidation and reduced insulin secretion.ConclusionsThis supports a newly identified abnormality of metabolism in CF – glucose induced redox imbalance to the oxidative state.
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影响因子：
16.2
作者：
Moran A;Brunzell C;Cohen RC;Katz M;Marshall BC;Onady G;Robinson KA;Sabadosa KA;Stecenko A;Slovis B;CFRD Guidelines Committee
通讯作者：
CFRD Guidelines Committee
影响因子：
8
作者：
Hart, Nathaniel J.;Aramandla, Radhika;Powers, Alvin C.
通讯作者：
Powers, Alvin C.
影响因子：
15.9
作者：
Borcherding, Dana C.;Siefert, Matthew E.;Ziady, Assem G.
通讯作者：
Ziady, Assem G.
影响因子：
3.1
作者：
Koch, C;Rainisio, M;Strandvik, B
通讯作者：
Strandvik, B
影响因子：
7.4
作者：
Jones, DP;Mody, VC;Sternberg, P
通讯作者：
Sternberg, P