Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes.
Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes.
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IL-7 和 IL-15 对骨髓增生异常综合征 T 细胞表型的影响
DOI：
10.18632/oncotarget.8459
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发表时间：
2016-05-10
期刊：
影响因子：
--
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Dong W;Ding T;Wu L;Ren X;Epling-Burnette PK;Yang L
T细胞表型异常是骨髓增生异常综合征(MDS)的特征之一。在本研究中，我们检测到MDS患者(n=20)血浆中IL-15的浓度高于健康对照组(n=20)。单纯CD_4~+和CD_8~+T细胞明显减少[CD_4~+T细胞16.11±6.56比24·11±7.18(p<；0.001)，CD_8+T细胞13.15±5.67比23·51±6.25(P<；0.001)]。幼稚T细胞减少和效应记忆T细胞增加与血浆IL-15水平显著相关。然后在体外检测IL-15和IL-7的作用。用IL-15处理MDS患者外周血单个核细胞15d。这种治疗显著降低了幼稚的CD_4~+(P<；0.001)和CD_8~+(P<；0.001)T细胞，并相应地增加了终末记忆CD_4~+和CD_8~+T细胞(P<；0.001)。经IL-7治疗后，幼稚的CD_4~+和CD_8~+(P<；0.001)T细胞均增加。我们的结果表明，暴露于高水平的IL-15可能参与了观察到的MDS的T细胞表型转换。IL-7可能是恢复MDS患者效应性免疫隔膜的有前景的候选治疗药物之一。
Aberrant T cell phenotype is one of the characteristics of myelodysplastic syndromes (MDS). In this study, we detected an increased concentration of IL-15 in the plasma of MDS patients (n = 20) compared with that in the plasma of healthy controls (n = 20). In MDS patients, reduced naïve CD4+ and CD8+ T cells [16.11 ± 6.56 vs. 24.11 ± 7.18 for CD4+ T cells (p < 0.001) and 13.15 ± 5.67 vs. 23.51 ± 6.25 for CD8+ T cells (p < 0.001)] were observed. The reduced naïve and increased effector memory T cells were significantly correlated with IL-15 plasma level. Then, the effect of IL-15 and IL-7 was tested in vitro. Peripheral blood mononuclear cells from MDS were treated for 15 days with IL-15. This treatment significantly decreased naïve CD4+ (p < 0.001) and CD8+ (p < 0.001) T cells and correspondingly increased terminal memory CD4+ and CD8+ T cells (p < 0.001). Treatment with IL-7 increased naïve CD4+ (p < 0.05) and CD8+ (p < 0.001) T cells. Our results indicated that exposure to high levels of IL-15 may be involved in the T cell phenotype conversion observed in MDS. IL-7 may be one of the promising therapeutic candidates for recovering the effector immune compartment in MDS patients.
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影响因子：
20.3
作者：
Greenberg, P;Cox, C;Bennett, J
通讯作者：
Bennett, J
影响因子：
3.2
作者：
Epling-Burnette, Pearlie K.;List, Alan F.
通讯作者：
List, Alan F.
白介素（IL）-15和IL-7联合调节记忆表型CD8+细胞的体内稳态增殖，但对于记忆表型CD4+细胞不需要。
影响因子：
15.3
作者：
Tan, Joyce T;Ernst, Bettina;Kieper, William C;LeRoy, Eric;Sprent, Jonathan;Surh, Charles D
通讯作者：
Surh, Charles D
影响因子：
3.7
作者：
De Bock M;Fillet M;Hannon M;Seidel L;Merville MP;Gothot A;Beguin Y;Baron F
通讯作者：
Baron F
影响因子：
30.8
作者：
Puel, A;Ziegler, SF;Leonard, WJ
通讯作者：
Leonard, WJ