Targeted regulation of tumor microenvironment through the inhibition of MDSCs by curcumin loaded self-assembled nano-filaments.
Targeted regulation of tumor microenvironment through the inhibition of MDSCs by curcumin loaded self-assembled nano-filaments.
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通过负载姜黄素的自组装纳米丝抑制 MDSC 来靶向调节肿瘤微环境。
DOI：
10.1016/j.mtbio.2022.100304
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发表时间：
2022-06
影响因子：
8.2
通讯作者：
Li, Xiaolin
中科院分区：
文献类型：
--
作者：
Wang, Tingting;Wang, Jia;Jiang, Hui;Ni, Mengnan;Zou, Yifan;Chen, Yanlong;Wu, Ting;Ding, Dan;Xu, Huae;Li, Xiaolin
肿瘤耐药的最重要原因之一是癌细胞诱导的免疫抑制。髓源性抑制细胞（MDSCs）是肿瘤微环境的重要调节因子，是肿瘤治疗的新靶点，在免疫抑制中发挥重要作用。姜黄素（curcumin，Cur）是一种特异性的MDSCs抑制剂，可以抑制MDSCs的数量和功能。此外，一种新的自组装纳米丝系统是通过共轭的Cur和自组装肽产生的。体内研究表明，姜黄素负载纳米丝（Nano-Cur）具有强大的抗肿瘤作用，可延迟肿瘤生长和延长生存期。Nano-Cur治疗后肿瘤微环境（TME）的免疫状态得到了很好的改善，T细胞增殖和活化增加，炎症介质如GM-CSF和IL-6的产生增加，这表明Nano-Cur通过调节和改善TME而有助于减轻肿瘤负荷。流式细胞术分析提示Nano-Cur处理后MDSCs水平降低，提示Nano-Cur的抗癌作用可能与抑制MDSCs在TME中的募集和积聚有关。因此，Nano-Cur可能是肺癌的一种新的治疗方法，需要对机制进行广泛的研究，以更好地了解TME如何影响肿瘤进展，并为抗癌治疗提供新的见解。Nano-Cur通过抑制TME中MDSC的抗癌作用的示意图。
One of the most important reasons underlying the resistance of tumors is the immune suppression induced by cancer cells. Myeloid-derived suppressor cells (MDSCs), which exerts pivotal functions in immunosuppression, is a key participator in tumor microenvironment and a novel target for cancer therapy. Here curcumin (Cur) was employed as a specific MDSCs repressor to inhibit the number and function of MDSCs. Moreover, a novel self-assembled nano-filament system was generated through the conjugation of Cur and a self-assembled peptide. In vivo study demonstrated the powerful antitumor effect of curcumin-loaded nano-filaments (Nano-Cur) with delayed tumor growth and longer survival. The immune status of tumor microenvironment (TME) was well improved by Nano-Cur treatment with increased T cell proliferation and activation as well as enhanced production of inflammatory mediators such as GM-CSF and IL-6, which revealed that Nano-Cur contributed to relieve the tumor burden by regulating and improving the TME. Furthermore, flow cytometry analysis implied the lower MDSCs levels under Nano-Cur treatment, which indicated that the anticancer effect of Nano-Cur may be associated with the inhibition of recruitment and accumulation of MDSCs in the TME. Therefore, Nano-Cur may be a novel therapeutic approach for lung cancer, and extensive studies of mechanisms are required to better understand how TME affects tumor progression and provide new insights into anticancer therapeutics. Schematic illustration of the anticancer effect of Nano-Cur by suppressing MDSCs in TME.
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影响因子：
2.6
作者：
Barar, Jaleh
通讯作者：
Barar, Jaleh
新型肿瘤靶向自组装肽纳米纤维作为有效姜黄素递送的载体
影响因子：
8
作者：
Liu J;Liu J;Xu H;Zhang Y;Chu L;Liu Q;Song N;Yang C
通讯作者：
Yang C
DOI：
10.1002/smll.201403799
发表时间：
2015-09
期刊：
Small (Weinheim an der Bergstrasse, Germany)
影响因子：
--
作者：
Klippstein R;Wang JT;El-Gogary RI;Bai J;Mustafa F;Rubio N;Bansal S;Al-Jamal WT;Al-Jamal KT
通讯作者：
Al-Jamal KT
影响因子：
16.6
作者：
Bronte V;Brandau S;Chen SH;Colombo MP;Frey AB;Greten TF;Mandruzzato S;Murray PJ;Ochoa A;Ostrand-Rosenberg S;Rodriguez PC;Sica A;Umansky V;Vonderheide RH;Gabrilovich DI
通讯作者：
Gabrilovich DI
影响因子：
38.3
作者：
Geng, Yan;Dalhaimer, Paul;Discher, Dennis E.
通讯作者：
Discher, Dennis E.