Sex differences in objective measures of sleep in post-traumatic stress disorder and healthy control subjects.
Sex differences in objective measures of sleep in post-traumatic stress disorder and healthy control subjects.
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DOI：
10.1111/jsr.12064
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发表时间：
2013-12
影响因子：
4.4
通讯作者：
Neylan TC
中科院分区：
文献类型：
--
作者：
Richards A;Metzler TJ;Ruoff LM;Inslicht SS;Rao M;Talbot LS;Neylan TC
越来越多的文献表明，性别对创伤后应激障碍的风险和相关的医疗共病负担有显著影响。先前的研究表明，创伤后应激障碍与慢波睡眠减少（SWS）有关，这可能对整体健康产生影响，而快速眼动睡眠异常与特定的创伤后应激障碍症状有关，但大多数研究都是在男性受试者中进行的。因此，我们试图比较男性和女性创伤后应激障碍受试者与年龄和性别匹配的对照组的客观睡眠测量。我们采用横断面2×2设计（PTSD/对照×女性/男性），纳入住院睡眠实验室的83名医学上健康、未服药的19-39岁成年人。脑电图目视分析显示，PTSD与较短的SWS持续时间（F(3,82)=7.63, p= 0.007）和SWS百分比（F(3,82)=6.11, p= 0.016）相关。在快速眼动持续时间（F(3,82)=4.08, p= 0.047）和快速眼动百分比（F(3,82)=4.30, p= 0.041）方面也存在性别互动的影响，这可以解释为创伤后应激障碍女性的快速眼动睡眠时间比对照组女性更长，而在男性受试者中没有发现这种差异。定量脑电图分析显示，创伤后应激障碍与非快速眼动睡眠δ谱能量较低相关（F(3,82)=6.79, p= 0.011）。SWS和delta的发现在男性中更为明显。移除合并重度抑郁症的PTSD受试者，他们的创伤后应激障碍严重程度更高，增强了delta效应，但降低了REM效应至无显著性。这些发现支持了先前的证据，即创伤后应激障碍与睡眠稳态功能受损有关，特别是在患有这种疾病的男性中。这些发现表明，性别相互作用对快速眼动的影响可能发生在更严重的PTSD或PTSD合并重度抑郁症的患者身上。
A growing literature shows prominent sex effects for risk for PTSD and associated medical comorbid burden. Prior research indicates that PTSD is associated with reduced slow wave sleep (SWS), which may have implications for overall health, and abnormalities in REM sleep, which have been implicated in specific PTSD symptoms, but most research has been conducted in male subjects. We therefore sought to compare objective measures of sleep in male and female PTSD subjects with age and sex-matched control subjects. We used a cross-sectional, 2×2 design (PTSD/control × female/male) involving 83 medically healthy, non-medicated adults aged 19–39 in the inpatient sleep laboratory. Visual analysis of EEG demonstrated that PTSD was associated with lower SWS duration (F(3,82)=7.63, p=.007) and SWS percent (F(3,82)=6.11, p=.016). There was also a group by sex interaction effect for REM duration (F(3,82)=4.08, p=.047) and REM percent (F(3,82)=4.30, p=.041), explained by greater REM sleep in PTSD females as compared to control females, a difference not seen in male subjects. Quantitative EEG analysis demonstrated that PTSD was associated with lower energy in the delta spectrum (F(3,82)=6.79, p=.011) in NREM sleep. SWS and delta findings were more pronounced in males. Removal of PTSD subjects with comorbid MDD, who had greater PTSD severity, strengthened delta effects but reduced REM effects to non-significance. These findings support prior evidence that PTSD is associated with impairment in the homeostatic function of sleep, especially in men with the disorder. These findings suggest that group by sex interaction effects on REM may occur with more severe PTSD or with PTSD comorbid with MDD.
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DOI：
10.1073/pnas.0706446105
发表时间：
2008-01-22
影响因子：
11.1
作者：
Tasali, Esra;Leproul, Rachel;Van Cauter, Eve
通讯作者：
Van Cauter, Eve
影响因子：
3.3
作者：
Mellman, Thomas A.;Pigeon, Wilfred R.;Nolan, Bruce
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影响因子：
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作者：
Woodward, SH;Murburg, MM;Bliwise, DL
通讯作者：
Bliwise, DL
影响因子：
10.3
作者：
Germain, A;Hall, M;Buysse, DJ
通讯作者：
Buysse, DJ
影响因子：
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作者：
Breslau, N;Roth, T;Roehrs, T
通讯作者：
Roehrs, T