TAP-mediated processing of exoerythrocytic antigens is essential for protection induced with radiation-attenuated Plasmodium sporozoites.
TAP-mediated processing of exoerythrocytic antigens is essential for protection induced with radiation-attenuated Plasmodium sporozoites.
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TAP 介导的红细胞外抗原加工对于辐射减弱的疟原虫子孢子诱导的保护至关重要。
DOI：
10.1002/eji.201545748
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发表时间：
2016
影响因子：
5.4
通讯作者：
Krzych,Urszula
中科院分区：
文献类型：
--
作者：
Pichugin,Alexander;Steers,Nick;DeLaVega,Patricia;Zarling,Stasya;Chalom,Isaac;Krzych,Urszula
依赖MHC-I类的CD8+T细胞对于辐射减毒疟原虫子孢子(RAS)诱导的小鼠疟疾模型的保护是必不可少的。除了环子孢子蛋白特异性CD8+T细胞的激活机制外，已被证明具有中介保护作用的其他红细胞外AGS的主要子孢子抗原(Ag)CD8+T细胞尚未得到彻底研究。具体地说，包括肝期(LS)AGS在内的红外型AGS的处理和呈现机制仍然知之甚少。我们假设，作为外源蛋白，LS AGS是通过TAP依赖的吞噬体胞浆途径或TAP非依赖的空泡交叉提呈途径来处理的。我们使用TAP缺陷小鼠来研究LS Ag介导的幼稚CD8+T细胞的诱导以及它们在子孢子攻击过程中的召回是通过TAP依赖还是TAP非依赖的途径发生的。根据功能属性，在伯氏疟原虫免疫过程中，CD8+T细胞通过TAP不依赖的途径被激活；然而，干扰素-γ+CD8+T细胞先前诱导了BYP。TAP缺陷小鼠的bergheiRAS对子孢子攻击不能被召回，小鼠成为寄生虫。在这些观察的基础上，我们认为TAP相关的Ag加工对于P诱导的无菌保护是必不可少的。伯格拉斯。
MHC class I dependent CD8+T cells are essential for protection induced by radiation‐attenuatedPlasmodiumsporozoites (RAS) in murine malaria models. Apart from the mechanism of activation of CD8+T cells specific for the circumsporozoite protein, the major sporozoite antigen (Ag), CD8+T cells specific for other exoerythrocytic Ags that have been shown to mediate protection have not been thoroughly investigated. Specifically, mechanisms of processing and presentation of exoerythrocytic Ags, which includes liver stage (LS) Ags, remain poorly understood. We hypothesize that as exogenous proteins, LS Ags are processed by mechanisms involving either the TAP‐dependent phagosomal‐to‐cytosol or TAP‐independent vacuolar pathway of cross‐presentation. We used TAP‐deficient mice to investigate whether LS Ag mediated induction of naïve CD8+T cells and their recall during sporozoite challenge occur by the TAP‐dependent or TAP‐independent pathways. On the basis of functional attributes, CD8+T cells were activated via the TAP‐independent pathway during immunizations withPlasmodium bergheiRAS; however, IFN‐γ+CD8+T cells previously induced byP. bergheiRAS in TAP‐deficient mice failed to be recalled against sporozoite challenge and the mice became parasitemic. On the basis of these observations, we propose that TAP‐associated Ag processing is indispensable for sterile protection induced withP. bergheiRAS.
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影响因子：
158.5
作者：
J. Benotti;W. Grossman;E. Braunwald;D. Davolos;A. Alousi
通讯作者：
A. Alousi
卡托普利和地高辛治疗轻至中度心力衰竭患者的比较效果。
DOI：
--
发表时间：
1988
期刊：
Journal of the American Medical Association (JAMA)
影响因子：
--
作者：
J. Cohn;M. Hawkins;H. Levine;J. Naughton;E. Rapaport;S. Goldstein;B. Pitt;R. Cody;P. Deedwania;L. Dennick;J. Franciosa;M. McGovern;J. J. Meyer;A. Gradman;B. Massie;M. Packer;J. Doherty;J. Gammill;W. Cooper;S. Engel;R. Fand;Barbara G. Hallows;L. Kerwin;Debra A. Soltesz;J. Parker;K. Lahey;E. Carbajal;P. Watson;R. Dibianco;J. Ronan;D. J. Donohue;K. Lindgren;L. Larca;J. Freitag;Donna Lindemuth;J. Lakier;H. Rosman;M. Włodkowski;R. Cody;S. Kubo;M. Clark;Kathleen Pondolfino;M. Wilén;Drexel Jordan;S. Das;J. Nicklas;Mary Kay Foley;M. Higginbotham;F. Cobb;Jean D. Wilson;D. Berkson;D. Obradovic;P. Hershinow;N. Nicholls;H. Ikram;I. Crozier;C. Pepine;John Culp;M. Limacher;Kathy Mulvehill;D. Farnham;Dorothy Adams;Norene Streicher;C. Shanley;M. Greenberg;J. Strain;M. Hewitt;Barbara Levine;D. Sharpe;R. Briant;R. Coxon;J. Cornyn;N. Topić;H. Willens;Denise Antonishen;D. Reinstein;H. Colfer;Karen E Graham;G. M. Perlow;H. Zarren;B. Bent;Marjorie Zicherman;B. Zaret;Deborah Lawrason;Pat Tellier;Kathy O'Keefe;S. Mohiuddin;L. Stengel;J. Madison;N. Carruthers;F. Elijovich;M. J. O'Sullivan;U. Elkayam;S. Rahimtoola;L. Weber;S. Gottlieb;Carol L. Brown;M. Jessup;S. Ulrich;Jane Kronenthal;D. Capaccio;Colin Grant;E. Gillie;Pat Wood;F. Fouad;Kay Petey
通讯作者：
Kay Petey
充血性心力衰竭患者致死性心律失常发病机制中的激素-电解质相互作用。
DOI：
10.1016/0002-9343(86)90337-2
发表时间：
1986
期刊：
The American journal of medicine
影响因子：
--
作者：
Packer,M;Gottlieb,SS;Kessler,PD
通讯作者：
Kessler,PD
正性肌力药物是否会对慢性充血性心力衰竭患者的生存产生不利影响？
影响因子：
24
作者：
R. Cody
通讯作者：
R. Cody
心力衰竭患者的β-肾上腺素能正性肌力反应：冠状动脉内输注多巴酚丁胺的研究。
影响因子：
20.1
作者：
Colucci,WS;Leatherman,GF;Ludmer,PL;Gauthier,DF
通讯作者：
Gauthier,DF