Bone mass, body composition and vitamin D status of ARV-naïve, urban, black South African women with HIV infection, stratified by CD₄ count.
Bone mass, body composition and vitamin D status of ARV-naïve, urban, black South African women with HIV infection, stratified by CD₄ count.
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DOI：
10.1007/s00198-013-2373-y
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发表时间：
2013-11
影响因子：
4
通讯作者：
Prentice, A.
中科院分区：
文献类型：
--
作者：
Hamill, M. M.;Ward, K. A.;Pettifor, J. M.;Norris, S. A.;Prentice, A.
这是第一份使用双能X线吸收测定法（DXA）检查非洲HIV感染妇女维生素D状况和骨量的报告，并有适当的HIV阴性对照组。与以前的出版物不同，它证明了在不同疾病阶段的HIV阳性患者与HIV阴性受试者的骨矿物质密度（BMD）或维生素D状态没有差异。据报道，艾滋病毒阳性患者的骨量低和维生素D状况差;这表明艾滋病毒或其治疗可能会增加骨质疏松症的风险，这是南非等艾滋病毒流行率高的国家的妇女特别关注的问题。我们描述了南非城市绝经前妇女的骨量和维生素D状况，这些妇女是HIV阳性但未接受抗逆转录病毒治疗（ARV）。这项研究是一个横断面测量骨密度和身体组成的DXA和维生素D状态的血清25-羟基维生素D（25（OH）D）浓度。受试者被招募到三个组中：HIV阴性（n = 98）和HIV阳性但CD 4细胞计数保留（非ARV; n = 74）或ARV启动前CD 4细胞计数低（ARV前; n = 75）。女性的平均（标准差（SD））年龄为32.1（7.2）岁。非抗逆转录病毒治疗组和抗逆转录病毒治疗前组的平均CD 4（SD）计数（×106/l）分别为412（91）和161（69）（p < 0.0001）。抗逆转录病毒治疗前的女性体重明显轻于其他两组，平均BMI也较低（p < 0.002）。与非ARV和HIV阴性受试者相比，ARV治疗前组的脂肪和瘦体重也显著减少（p ≤ 0.05）。完全校正后，两组间任何部位的BMD均无显著差异（p > 0.05），两组间维生素D状况也无显著差异（p > 0.05）;队列25（OH）D平均值（SD）为60（18）nmol/l。与以前的研究相反，这些HIV阳性妇女的BMD或25（OH）D浓度并不低于HIV阴性对照组，尽管ARV前组体重较轻，BMI较低。本文的在线版本（doi：10.1007/s 00198 -013-2373-y）包含补充材料，可供授权用户使用。
This is the first report examining vitamin D status and bone mass in African women with HIV infection using dual-energy X-ray absorptiometry (DXA) with an appropriate HIV-negative control group. Unlike previous publications, it demonstrates no difference in bone mineral density (BMD) or vitamin D status in HIV-positive patients, at different disease stages, vs. HIV-negative subjects. Low bone mass and poor vitamin D status have been reported among HIV-positive patients; suggesting HIV or its treatment may increase the risk of osteoporosis, a particular concern for women in countries with high HIV prevalence such as South Africa. We describe bone mass and vitamin D status in urban premenopausal South African women, who were HIV positive but not on antiretroviral therapy (ARV). This study is a cross-sectional measurement of BMD and body composition by DXA and vitamin D status by serum 25-hydroxyvitamin D (25(OH)D) concentration. Subjects were recruited into three groups: HIV negative (n = 98) and HIV positive with preserved CD4 cell count (non-ARV; n = 74) or low CD4 cell counts prior to ARV initiation (pre-ARV; n = 75). The mean (standard deviation (SD)) age of women was 32.1 (7.2) years. Mean CD4 (SD) counts (×106/l) were 412 (91) and 161 (69) in non-ARV and pre-ARV groups (p < 0.0001). Pre-ARV women were significantly lighter and had lower mean BMI than the other two groups (p < 0.002). The pre-ARV group also had significantly less fat and lean mass compared with non-ARV and HIV-negative subjects (p ≤ 0.05). After full adjustment, there were no significant differences in BMD at any site (p > 0.05) between the groups, nor was vitamin D status significantly different between groups (p > 0.05); the mean (SD) cohort 25(OH)D being 60 (18) nmol/l. Contrary to previous studies, these HIV-positive women did not have lower BMD or 25(OH)D concentrations than HIV-negative controls, despite the pre-ARV group being lighter with lower BMI. The online version of this article (doi:10.1007/s00198-013-2373-y) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/j.amjmed.2011.06.013
发表时间：
2011-11
期刊：
The American journal of medicine
影响因子：
--
作者：
Compston JE;Watts NB;Chapurlat R;Cooper C;Boonen S;Greenspan S;Pfeilschifter J;Silverman S;Díez-Pérez A;Lindsay R;Saag KG;Netelenbos JC;Gehlbach S;Hooven FH;Flahive J;Adachi JD;Rossini M;Lacroix AZ;Roux C;Sambrook PN;Siris ES;Glow Investigators
通讯作者：
Glow Investigators
影响因子：
56.9
作者：
Liu, PT;Stenger, S;Modlin, RL
通讯作者：
Modlin, RL
影响因子：
3.2
作者：
Poopedi, Machuene A.;Norris, Shane A.;Pettifor, John M.
通讯作者：
Pettifor, John M.
影响因子：
3.1
作者：
Brown, Todd T;McComsey, Grace A
通讯作者：
McComsey, Grace A
影响因子：
11.8
作者：
Arnsten, JH;Freeman, R;Schoenbaum, EE
通讯作者：
Schoenbaum, EE