Neurodevelopmental findings in children 20-30 months of age with postnatal Zika infection at 1-12 months of age, Colombia, September-November 2017.
Neurodevelopmental findings in children 20-30 months of age with postnatal Zika infection at 1-12 months of age, Colombia, September-November 2017.
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DOI：
10.1111/ppe.12690
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发表时间：
2021-01
影响因子：
2.8
通讯作者：
Ospina Martínez ML
中科院分区：
文献类型：
--
作者：
Pacheco O;Newton SM;Daza M;Cates JE;Reales JAM;Burkel VK;Mercado M;Godfred-Cato S;Gonzalez M;Anderson KN;Woodworth KR;Valencia D;Tong VT;Gilboa SM;Osorio MB;Rodríguez DYS;Prieto-Alvarado FE;Moore CA;Honein MA;Ospina Martínez ML
妊娠期间感染寨卡病毒（ZIKV）可导致婴儿大脑和眼睛异常，并与暴露婴儿的不良神经发育结果相关。关于ZIKV对出生后第一年内感染的儿童的影响的证据有限。为了确定在婴儿期出生后感染ZIKV的儿童在幼儿期是否发生任何不良神经发育结果，考虑到ZIKV感染的神经毒性以及婴儿期和幼儿期发生的快速大脑发育。哥伦比亚国家健康研究所（INS）在2017年9月至11月期间进行了健康和发育筛查，以评估60名年龄在20-30个月的儿童，他们在1-12个月时患有实验室确认的产后症状性ZIKV感染。我们检查了不良神经系统，听力，眼睛和发育结果的频率，以及寨卡症状发作时的年龄与发育结果之间的关系。60名儿童中有9名（15.0%）在神经系统、听力或眼科检查中出现不良结局。在47名没有这些不良结果的儿童中，有6名（12.8%）接受了有效的发育筛查，他们在听力语言领域的警觉评分表明需要进行额外的发育评估。神经、听力、视力和发育检查结果表明结果令人放心。由于出生后感染ZIKV的儿童的神经发育结果的全谱仍然未知，因此建议常规儿科护理监测这些儿童的发育，以确保早期识别任何不良神经发育结果。
Zika virus (ZIKV) infection during pregnancy can cause infant brain and eye abnormalities and has been associated with adverse neurodevelopmental outcomes in exposed infants. Evidence is limited on ZIKV’s effects on children infected postnatally within the first year of life. To determine whether any adverse neurodevelopmental outcomes occurred in early childhood for children infected postnatally with ZIKV during infancy, given the neurotoxicity of ZIKV infection and the rapid brain development that occurs in infancy and early childhood. The Colombia Instituto Nacional de Salud (INS) conducted health and developmental screenings between September and November 2017 to evaluate 60 children at ages 20–30 months who had laboratory-confirmed symptomatic postnatal ZIKV infection at ages 1–12 months. We examined the frequency of adverse neurologic, hearing, eye, and developmental outcomes as well as the relationship between age at Zika symptom onset and developmental outcomes. Nine of the 60 (15.0%) children had adverse outcomes on the neurologic, hearing, or eye examination. Six of the 47 (12.8%) children without these adverse findings, and who received a valid developmental screening, had an alert score in the hearing-language domain which signals the need for additional developmental evaluation. Neurologic, hearing, eye, and developmental findings suggest reassuring results. Since the full spectrum of neurodevelopmental outcomes in children postnatally infected with ZIKV remains unknown, routine paediatric care is advised to monitor the development of these children to ensure early identification of any adverse neurodevelopmental outcomes.
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影响因子：
17.1
作者：
Mavigner M;Raper J;Kovacs-Balint Z;Gumber S;O'Neal JT;Bhaumik SK;Zhang X;Habib J;Mattingly C;McDonald CE;Avanzato V;Burke MW;Magnani DM;Bailey VK;Watkins DI;Vanderford TH;Fair D;Earl E;Feczko E;Styner M;Jean SM;Cohen JK;Silvestri G;Johnson RP;O'Connor DH;Wrammert J;Suthar MS;Sanchez MM;Alvarado MC;Chahroudi A
通讯作者：
Chahroudi A
影响因子：
168.9
作者：
Franca, Giovanny V. A.;Schuler-Faccini, Lavinia;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
影响因子：
158.5
作者：
Pacheco, Oscar;Beltran, Mauricio;Ospina Martinez, Martha L.
通讯作者：
Ospina Martinez, Martha L.
影响因子：
2.8
作者：
Tolosa, Natalia;Tinker, Sarah C.;Ospina Martinez, Martha L.
通讯作者：
Ospina Martinez, Martha L.
影响因子：
33.7
作者：
Sharp, Tyler M.;Fischer, Marc;Waterman, Stephen H.
通讯作者：
Waterman, Stephen H.