Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques.
Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques.
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DOI：
10.1126/scitranslmed.aao6975
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发表时间：
2018-04-04
影响因子：
17.1
通讯作者：
Chahroudi A
中科院分区：
文献类型：
--
作者：
Mavigner M;Raper J;Kovacs-Balint Z;Gumber S;O'Neal JT;Bhaumik SK;Zhang X;Habib J;Mattingly C;McDonald CE;Avanzato V;Burke MW;Magnani DM;Bailey VK;Watkins DI;Vanderford TH;Fair D;Earl E;Feczko E;Styner M;Jean SM;Cohen JK;Silvestri G;Johnson RP;O'Connor DH;Wrammert J;Suthar MS;Sanchez MM;Alvarado MC;Chahroudi A
寨卡病毒（ZIKV）流行与胎儿脑病变和其他严重出生缺陷有关，被归类为先天性ZIKV综合征。已经报道了婴儿和儿童的产后ZIKV感染;然而，缺乏关于感染后的脑解剖结构、功能和行为结果的数据。我们表明，与年龄匹配的对照组相比，出生后ZIKV感染的婴儿恒河猴（RM）导致中枢神经系统的持续结构和功能改变。我们证明了ZIKV在婴儿RM中的淋巴和神经嗜性以及外周和中枢神经系统中的组织病理学异常，包括炎性浸润、星形胶质细胞增生和沃勒变性。结构和静息状态功能性磁共振成像（MRI/rs-fMRI）显示侧脑室持续扩大，特定脑区的成熟变化，以及参与情绪行为和唤醒功能的脑区之间的功能连接（FC）改变，包括在ZIKV RNA从外周血中清除后几个月，两个ZIKV感染的婴儿RM中有两个的杏仁核-海马连接减弱。ZIKV感染还导致对急性应激的物种典型情绪反应性的明显改变，这是由弱杏仁核-海马FC预测的。我们证明，在这个模型中，婴儿的出生后ZIKV感染影响神经发育，这表明有必要对儿科病例进行长期临床监测。
The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid- and neuro-tropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration. Structural and resting state functional Magnetic Resonance Imaging (MRI/rs-fMRI) show persistent enlargement of lateral ventricles, maturational changes in specific brain regions, and altered functional connectivity (FC) between brain areas involved in emotional behavior and arousal functions, including weakened amygdala-hippocampal connectivity in two out of two ZIKV-infected infant RMs several months after clearance of ZIKV RNA from peripheral blood. ZIKV infection also results in distinct alterations in the species-typical emotional reactivity to acute stress, which were predicted by the weak amygdala-hippocampal FC. We demonstrate that postnatal ZIKV infection of infants in this model impacts neurodevelopment, suggesting that long-term clinical monitoring of pediatric cases is warranted.
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影响因子：
3.7
作者：
Coffey LL;Pesavento PA;Keesler RI;Singapuri A;Watanabe J;Watanabe R;Yee J;Bliss-Moreau E;Cruzen C;Christe KL;Reader JR;von Morgenland W;Gibbons AM;Allen AM;Linnen J;Gao K;Delwart E;Simmons G;Stone M;Lanteri M;Bakkour S;Busch M;Morrison J;Van Rompay KK
通讯作者：
Van Rompay KK
DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
2.7
作者：
Bliss-Moreau E;Moadab G;Santistevan A;Amaral DG
通讯作者：
Amaral DG
影响因子：
9.8
作者：
Alvarado, M. C.;Murphy, K. L.;Baxter, M. G.
通讯作者：
Baxter, M. G.
影响因子：
3.5
作者：
Aragao, M. F. V. V.;Holanda, A. C.;Costello, A.
通讯作者：
Costello, A.