Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.
Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.
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DOI：
10.1007/s00213-008-1247-z
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发表时间：
2008-11
影响因子：
3.4
通讯作者：
Geyer, Mark A.
中科院分区：
文献类型：
--
作者：
Halberstadt, Adam L.;Buell, Mahalah R.;Masten, Virginia L.;Risbrough, Victoria B.;Geyer, Mark A.
被称为ayahuasca的致幻茶是由精神活性植物的组合制成的，这些植物提供活性成分N，N-二甲基色胺（DMT）和5-甲氧基-DMT（5-MeO-DMT），以及单胺氧化酶（MAO）抑制剂（MAOI）骆驼蓬碱和骆驼蓬碱用于口服活性。本研究使用行为模式监测器（BPM），它可以分析自发活动和探索的模式，研究了5-MeO-DMT与MAOIs结合在大鼠中的作用。还使用5-羟色胺（5-HT）1A拮抗剂WAY-100635（1.0 mg/kg）和5-HT 2A拮抗剂MDL 11，939（1.0 mg/kg）进行了相互作用研究，以评估这些受体对MAOI处理动物中5-MeO-DMT行为效应的各自贡献。5-MeO-DMT（0.01、0.1和1.0 mg/kg）降低小鼠的自发活动和行为。在大鼠预处理的行为失活剂量的harlavin（0.1毫克/公斤），1.0毫克/公斤5-MeO-DMT有双相影响的自发活动，最初减少运动，然后增加活动随着时间的推移。选择性单胺氧化酶抑制剂氯吉兰（clorgyline）也具有使5-MeO-DMT转变为双相运动模式的能力，而选择性单胺氧化酶抑制剂（-）-丙炔苯丙胺则无效。用MDL 11，939预处理可阻断由1.0 mg/kg 5-MeO-DMT和0.3 mg/kg氯吉林组合诱导的晚期活动过度。WAY-100635预处理未能减轻早期活动减退或晚期活动过度。哈洛宁改变5-MeO-DMT的行为效应的能力是通过抑制MAOA介导的。此外，5-HT 2A受体负责在MAOA抑制剂存在下由5-MeO-DMT诱导的晚期活动过度。
The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as the monoamine oxidase (MAO) inhibitors (MAOIs) harmine and harmaline for oral activity. The present study examined the effects of 5-MeO-DMT in combination with MAOIs in rats using the Behavioral Pattern Monitor (BPM), which enables analyses of patterns of locomotor activity and exploration. Interaction studies using the serotonin (5-HT)1A antagonist WAY-100635 (1.0 mg/kg) and the 5-HT2A antagonist MDL 11,939 (1.0 mg/kg) were also performed to assess the respective contributions of these receptors to the behavioral effects of 5-MeO-DMT in MAOI-treated animals. 5-MeO-DMT (0.01, 0.1, and 1.0 mg/kg) decreased locomotor activity and investigatory behavior. In rats pretreated with a behaviorally inactive dose of harmaline (0.1 mg/kg), 1.0 mg/kg 5-MeO-DMT had biphasic effects on locomotor activity, initially reducing locomotion and then increasing activity as time progressed. The ability of harmaline to shift 5-MeO-DMT to a biphasic locomotor pattern was shared by the selective MAOA inhibitor clorgyline, whereas the selective MAOB inhibitor (−)-deprenyl was ineffective. The late hyperactivity induced by the combination of 1.0 mg/kg 5-MeO-DMT and 0.3 mg/kg clorgyline was blocked by pretreatment with MDL 11,939. Pretreatment with WAY-100635 failed to attenuate either the early hypoactivity or the late hyperactivity. The ability of harmaline to modify the behavioral effects of 5-MeO-DMT is mediated by inhibition of MAOA. Further, 5-HT2A receptors are responsible for the late hyperactivity induced by 5-MeO-DMT in the presence of MAOA inhibitors.
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影响因子：
1.9
作者：
ADAMS, LM;GEYER, MA
通讯作者：
GEYER, MA
影响因子：
3.9
作者：
Kim, H;Sablin, SO;Ramsay, RR
通讯作者：
Ramsay, RR
DOI：
10.1081/clt-120030949
发表时间：
2004-01-01
期刊：
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY
影响因子：
--
作者：
Brush, DE;Bird, SB;Boyer, EW
通讯作者：
Boyer, EW
色胺衍生物与血清素转运蛋白物种变体的相互作用表明跨膜结构域 I 参与底物识别
影响因子：
3.6
作者：
Adkins, EM;Barker, EL;Blakely, RD
通讯作者：
Blakely, RD
DOI：
10.1016/s1056-8719(02)00159-4
发表时间：
2001-07-01
影响因子：
1.9
作者：
Eckler, JR;Greizerstein, H;Winter, JC
通讯作者：
Winter, JC