Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients.
Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients.
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DOI：
10.1038/sj.bjc.6603065
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发表时间：
2006-04-10
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
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前梯度蛋白-2（AGR 2）可被雌激素诱导，其本身可在大鼠乳腺癌模型中诱导转移。在这里，重组人AGR 2的兔抗体被用来评估其预后的意义，在一个回顾性队列的351例乳腺癌患者接受辅助激素治疗。该抗体对66%的乳腺癌有不同程度的染色。肿瘤中的阳性癌细胞百分比与AGR 2 mRNA水平（斯皮尔曼等级相关，P=0.0007）和蛋白水平（线性回归分析r2=0.95，P=0.0002）直接相关。AGR 2染色与雌激素受体α（ERα）染色和低组织学分级显著相关（Fisher精确检验P<0.0001）。在ERα阳性病例中，而不是ERα阴性病例中，当细分为AGR 2的单独染色类别时，患者生存率随染色增加而显著进行性降低（对数秩检验，P=0.006）。AGR 2染色与10年期间患者死亡的显著相关性（对数秩检验P=0.007，风险比=3）仅在6年随访时才变得显著。这可能是由于在较早的时间停止辅助激素治疗，导致转移诱导蛋白AGR 2的不良再表达。
The anterior gradient protein-2 (AGR2) is inducible by oestrogen and itself can induce metastasis in a rat model for breast cancer. Here, a rabbit antibody to recombinant human AGR2 was used to assess its prognostic significance in a retrospective cohort of 351 breast cancer patients treated by adjuvant hormonal therapy. The antibody stains 66% of breast carcinomas to varying degrees. The percentage of positive carcinoma cells in tumours directly correlates with the level of AGR2 mRNA (Spearman's rank correlation, P=0.0007) and protein (linear regression analysis r2=0.95, P=0.0002). There is a significant association of staining of carcinomas for AGR2 with oestrogen receptor α (ERα) staining and with low histological grade (both Fisher's Exact test P<0.0001). In the ERα-positive cases, but not the ERα-negative cases, when subdivided into the separate staining classes for AGR2, there is a significantly progressive decrease in patient survival with increased staining (log rank test, P=0.006). The significant association of staining for AGR2 with patient death over a 10-year period (log rank test P=0.007, hazard ratio=3) only becomes significant at 6 years of follow-up. This may be due to the cessation of adjuvant hormonal therapy at an earlier time, resulting in adverse re-expression of the metastasis-inducing protein AGR2.
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影响因子：
8.8
作者：
Martin L;Green B;Renshaw C;Lowe D;Rudland P;Leinster SJ;Winstanley J
通讯作者：
Winstanley J
影响因子：
8.8
作者：
O'Neill, PA;Davies, MPA;Shaaban, AM;Innes, H;Torevell, A;Sibson, DR;Foster, CS
通讯作者：
Foster, CS
影响因子：
4.8
作者：
El-Tanani, M;Fernig, DG;Rudland, P
通讯作者：
Rudland, P
影响因子：
8.8
作者：
Rudland, P S;Dunnington, D J;Kim, U;Gusterson, B A;O'Hare, M J;Monaghan, P
通讯作者：
Monaghan, P
影响因子：
8.8
作者：
Anandappa, S. Y.;Winstanley, J. H. R.;Leinster, S.;Green, B.;Rudland, P. S.;Barraclough, R.
通讯作者：
Barraclough, R.