Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain.
Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain.
复制标题
DOI：
10.1002/nbm.1646
复制
发表时间：
2011-08
影响因子：
2.9
通讯作者：
Terpstra, Melissa
中科院分区：
文献类型：
--
作者：
Emir, Uzay E.;Raatz, Susan;McPherson, Susan;Hodges, James S.;Torkelson, Carolyn;Tawfik, Pierre;White, Tonya;Terpstra, Melissa
在这项研究中，使用双编辑1H MRS在4 T下对健康年轻[年龄（平均值±标准差）= 20.4 ± 1.4岁]和老年（年龄= 76.6 ± 6.1岁）人类受试者的枕叶皮质中的抗坏血酸盐（Asc）和谷胱甘肽（GSH）浓度进行了无创定量。老年受试者的GSH浓度低于年轻受试者（p <0.05）。Asc浓度与年龄无显著相关性。此外，老年人的乳酸（Lac）浓度高于年轻受试者。较低的GSH和较高的Lac浓度是对氧化损伤和受损的线粒体呼吸的保护缺陷的迹象。在何种程度上所观察到的浓度差异可能与生理差异和方法的文物进行了讨论。总之，GSH和Asc浓度进行了比较，第一次在非侵入性的年轻与老年受试者。
In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified noninvasively using double-edited 1H MRS at 4 T in the occipital cortex of healthy young [age (mean ± standard deviation) = 20.4 ± 1.4 years] and elderly (age = 76.6 ± 6.1 years) human subjects. Elderly subjects had a lower GSH concentration than younger subjects (p < 0.05). The Asc concentration was not significantly associated with age. Furthermore, the lactate (Lac) concentration was higher in elderly than young subjects. Lower GSH and higher Lac concentrations are indications of defective protection against oxidative damage and impaired mitochondrial respiration. The extent to which the observed concentration differences could be associated with physiological differences and methodological artifacts is discussed. In conclusion, GSH and Asc concentrations were compared noninvasively for the first time in young vs elderly subjects.
登录
查看更多内容
影响因子：
3.3
作者：
GRUETTER, R
通讯作者：
GRUETTER, R
影响因子：
3.6
作者：
Harrison, F. E.;Hosseini, A. H.;May, J. M.
通讯作者：
May, J. M.
影响因子：
3.3
作者：
Henry, PG;Marjanska, M;Ugurbil, K
通讯作者：
Ugurbil, K
影响因子：
7.4
作者：
Harrison FE;May JM
通讯作者：
May JM
影响因子：
2.9
作者：
Emir, Uzay E.;Deelchand, Dinesh;Henry, Pierre-Gilles;Terpstra, Melissa
通讯作者：
Terpstra, Melissa