Larger left hippocampal presubiculum is associated with lower risk of antisocial behavior in healthy adults with childhood conduct history.
Larger left hippocampal presubiculum is associated with lower risk of antisocial behavior in healthy adults with childhood conduct history.
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DOI：
10.1038/s41598-023-33198-9
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发表时间：
2023-04-15
影响因子：
4.6
通讯作者：
Rajimehr, Reza
中科院分区：
文献类型：
--
作者：
Abdolalizadeh, AmirHussein;Moradi, Kamyar;Ohadi, Mohammad Amin Dabbagh;Mirfazeli, Fatemeh Sadat;Rajimehr, Reza
行为障碍（CD）被定义为儿童时期的攻击性，反社会和违规行为。它是成年后发展为反社会人格障碍（ASPD）的主要危险因素。然而，近一半的CD不会发展ASPD。确定逆转因素似乎对适当的干预至关重要。我们从人类连接组计划中确定了40名儿童CD病史（CC）和1166名对照受试者（HC）。他们的精神，情绪，冲动，和人格特征提取。进行了情绪识别任务-fMRI分析。我们还对35例CC和69例人口统计学匹配的HC的海马和杏仁核进行了亚区分析。CC科目得分显着较高的反社会相关的评价。杏仁核和海马的任务功能磁共振成像激活没有差异。CC有较大的左海马子字段：前下托，CA 3，CA 4，和齿状回。此外，一个互动模型揭示了一个显着的前下托体积×组与反社会，侵略性和宜人性的分数。我们的研究表明，有CD病史的健康年轻人仍然表现出某些形式的反社会行为，左海马子区域较大，包括前下托，这也解释了反社会行为的变异性。这些较大的左海马子区域体积可能对CD向ASPD的转换起保护作用。
Conduct Disorder (CD) is defined as aggressive, antisocial, and rule-breaking behavior during childhood. It is a major risk factor for developing antisocial personality disorder (ASPD) in adulthood. However, nearly half the CDs do not develop ASPD. Identification of reversion factors seems crucial for proper interventions. We identified 40 subjects with childhood history of CD (CC) and 1166 control subjects (HC) from Human Connectome Project. Their psychiatric, emotional, impulsivity, and personality traits were extracted. An emotion recognition task-fMRI analysis was done. We also did subregion analysis of hippocampus and amygdala in 35 CC and 69 demographically matched HCs. CC subjects scored significantly higher in antisocial-related evaluations. No differences in task-fMRI activation of amygdala and hippocampus were observed. CCs had larger subfields of the left hippocampus: presubiculum, CA3, CA4, and dentate gyrus. Further, an interaction model revealed a significant presubiculum volume × group association with antisocial, aggression, and agreeableness scores. Our study shows that healthy young adults with a prior history of CD still exhibit some forms of antisocial-like behavior with larger left hippocampal subfields, including presubiculum that also explains the variability in antisocial behavior. These larger left hippocampal subfield volumes may play a protective role against CD to ASPD conversion.
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影响因子：
5.7
作者：
de Oliveira-Souza, Ricardo;Hare, Robert D.;Moll, Jorge
通讯作者：
Moll, Jorge
影响因子：
1.9
作者：
Blair, Robert J. R.
通讯作者：
Blair, Robert J. R.
影响因子：
25
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Glasser MF;Smith SM;Marcus DS;Andersson JL;Auerbach EJ;Behrens TE;Coalson TS;Harms MP;Jenkinson M;Moeller S;Robinson EC;Sotiropoulos SN;Xu J;Yacoub E;Ugurbil K;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
4.8
作者：
Chalavi, Sima;Vissia, Eline M.;Giesen, Mechteld E.;Nijenhuis, Ellert R. S.;Draijer, Nel;Cole, James H.;Dazzan, Paola;Pariante, Carmine M.;Madsen, Sarah K.;Rajagopalan, Priya;Thompson, Paul M.;Toga, Arthur W.;Veltman, Dick J.;Reinders, Antje A. T. S.
通讯作者：
Reinders, Antje A. T. S.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y