Abnormal hippocampal morphology in dissociative identity disorder and post-traumatic stress disorder correlates with childhood trauma and dissociative symptoms.
Abnormal hippocampal morphology in dissociative identity disorder and post-traumatic stress disorder correlates with childhood trauma and dissociative symptoms.
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DOI：
10.1002/hbm.22730
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发表时间：
2015-05
影响因子：
4.8
通讯作者：
Reinders, Antje A. T. S.
中科院分区：
文献类型：
--
作者：
Chalavi, Sima;Vissia, Eline M.;Giesen, Mechteld E.;Nijenhuis, Ellert R. S.;Draijer, Nel;Cole, James H.;Dazzan, Paola;Pariante, Carmine M.;Madsen, Sarah K.;Rajagopalan, Priya;Thompson, Paul M.;Toga, Arthur W.;Veltman, Dick J.;Reinders, Antje A. T. S.
在创伤后应激障碍（PTSD）和分离性身份识别障碍（DID）患者中，海马体积较小，但海马体积减小的区域特异性以及与分离症状和/或儿童创伤严重程度的相关性仍不清楚。研究人员分析了33名门诊患者（17名DID患者和16名仅患有PTSD的患者）和28名健康对照（HC）的脑结构MRI扫描，所有患者的年龄、性别和教育程度都匹配。DID患者符合PTSD（PTSD-DID）标准。提取海马全局和子域体积和形状测量值。我们发现，与HC相比，所有33例患者（左侧：6.75%;右侧：8.33%）的整体海马体积显著较小。PTSD-DID（左：10.19%;右：与HC组相比，PTSD组（左：7.11%;右：7.31%）和PTSD组（左：11.37%;右：7.31%）的整体海马体积显著较小。与HC相比，PTSD-DID在CA 2 -3、CA 4-DG和（前）下托中具有异常形状和显著较小的体积。在患者组中，较小的整体和子区域海马体积与儿童期创伤和分离症状的严重程度显著相关。这些研究结果支持儿童创伤相关的病因异常海马形态在PTSD和DID，并可以进一步了解这些疾病的神经生物学机制。
Smaller hippocampal volume has been reported in individuals with posttraumatic stress disorder (PTSD) and dissociative identity disorder (DID), but the regional specificity of hippocampal volume reductions and the association with severity of dissociative symptoms and/or childhood traumatization are still unclear. Brain structural MRI scans were analyzed for 33 outpatients (17 with DID and 16 with PTSD only) and 28 healthy controls (HC), all matched for age, sex, and education. DID patients met criteria for PTSD (PTSD-DID). Hippocampal global and subfield volumes and shape measurements were extracted. We found that global hippocampal volume was significantly smaller in all 33 patients (left: 6.75%; right: 8.33%) compared to HC. PTSD-DID (left: 10.19%; right: 11.37%) and PTSD-only with a history of childhood traumatization (left: 7.11%; right: 7.31%) had significantly smaller global hippocampal volume relative to HC. PTSD-DID had abnormal shape and significantly smaller volume in the CA2-3, CA4-DG and (pre)subiculum compared to HC. In the patient groups, smaller global and subfield hippocampal volumes significantly correlated with higher severity of childhood traumatization and dissociative symptoms. These findings support a childhood trauma-related etiology for abnormal hippocampal morphology in both PTSD and DID and can further the understanding of neurobiological mechanisms involved in these disorders.
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影响因子：
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