Are early childhood stunting and catch-up growth associated with school age cognition?-Evidence from an Indian birth cohort.
Are early childhood stunting and catch-up growth associated with school age cognition?-Evidence from an Indian birth cohort.
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DOI：
10.1371/journal.pone.0264010
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Kang G
中科院分区：
文献类型：
--
作者：
Koshy B;Srinivasan M;Gopalakrishnan S;Mohan VR;Scharf R;Murray-Kolb L;John S;Beulah R;Muliyil J;Kang G
全球有数百万儿童，尤其是亚洲次大陆的儿童，很容易出现儿童早期发育迟缓的情况。关于儿童期追赶性生长与学龄认知之间的关系，存在相互矛盾的报道。 2010 年至 2012 年间，从印度韦洛尔城市贫民窟招募的社区出生队列被随访至 9 岁。根据常规人体测量，计算每个儿童 2 岁、5 岁和 9 岁时的发育迟缓状况。使用印度儿童马林智力量表 (MISIC) 在 9 岁时评估认知能力。根据每个时间点的发育迟缓和追赶性生长，将儿童分为几组，并利用回归模型评估他们与 9 岁时认知的关系。在本次分析的203名儿童中，94/203（46.31%）的儿童在2岁时发育迟缓，其中39.36%的儿童在5岁时出现追赶性生长，38.30%的儿童在9岁时出现追赶性生长。大约 10% 的人群在所有时间点都发育迟缓。在多变量分析中，与从未发育迟缓的儿童相比，2、5 和 9 岁时发育迟缓的儿童的言语和总智商 (IQ) 分数显着降低 4.6 分。两岁时发育迟缓后出现追赶性生长的儿童的认知得分高于那些在整个童年时期持续发育迟缓的儿童。这项研究表明，儿童期持续发育迟缓与 9 岁时儿童认知智商降低 4-5 分有关。与持续发育迟缓的儿童相比，追赶性生长的儿童从早期发育迟缓中恢复可以防止这些儿童的认知得分进一步降低。除了针对学龄前儿童和学龄儿童的持续营养补充计划外，婴儿后期和幼儿早期的营养补充可以改善弱势群体的儿童发育迟缓和认知能力。
Millions of children worldwide especially in the Asian subcontinent are vulnerable to early childhood stunting. There are contradictory reports of the association between catch-up growth in childhood and school age cognition. A community-based birth cohort recruited between 2010 and 2012 from urban slums in Vellore, India was followed up until 9 years of age. From regular anthropometric measurements, stunting status for each individual child was calculated at 2, 5 and 9 years. Cognition was assessed at 9 years of age using the Malin’s Intelligence Scale for Indian Children (MISIC). Children were divided into groups based on stunting at each time point as well as catch-up growth, and a regression model was utilised to evaluate their association with cognition at 9 years. Among 203 children included in this analysis, 94/203 (46.31%) children were stunted at 2 years of age, of whom 39.36% had a catch-up growth at 5 years of age, and 38.30% at 9 years. Around 10% of the cohort remained stunted at all time points. In the multivariable analysis, children who were stunted at 2, 5 and 9 years had a significantly lower verbal and total intelligence quotient (IQ) scores by 4.6 points compared to those who were never stunted. Children with catch up growth following stunting at 2 years had higher cognition scores than those who were persistently stunted throughout the childhood. This study showed persistent stunting in childhood was associated with lowering of 4–5 IQ points in childhood cognition at 9 years of age. Recovery from early life stunting in children with catch up growth prevented further lowering of cognition scores in these children compared to persistently stunted children. Nutritional supplementation during late infancy and early toddlerhood in addition to continuing nutritional supplementation programmes for preschool and school children can improve childhood stunting and cognitive abilities in vulnerable populations.
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DOI：
10.1016/s0140-6736(16)31389-7
发表时间：
2017-01-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Black MM;Walker SP;Fernald LCH;Andersen CT;DiGirolamo AM;Lu C;McCoy DC;Fink G;Shawar YR;Shiffman J;Devercelli AE;Wodon QT;Vargas-Barón E;Grantham-McGregor S;Lancet Early Childhood Development Series Steering Committee
通讯作者：
Lancet Early Childhood Development Series Steering Committee
影响因子：
2.5
作者：
Casale, Daniela;Desmond, Chris;Richter, Linda M.
通讯作者：
Richter, Linda M.
影响因子：
168.9
作者：
Adair, Linda S.;Fall, Caroline H. D.;Osmond, Clive;Stein, Aryeh D.;Martorell, Reynaldo;Ramirez-Zea, Manuel;Sachdev, Harshpal Singh;Dahly, Darren L.;Bas, Isabelita;Norris, Shane A.;Micklesfield, Lisa;Hallal, Pedro;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
影响因子：
1.9
作者：
Casale, D.;Desmond, C.;Richter, L.
通讯作者：
Richter, L.
影响因子：
11.8
作者：
Acosta, Angel Mendez;Chavez, Cesar Banda;Shrestha, Sanjaya Kumar
通讯作者：
Shrestha, Sanjaya Kumar