Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease.
Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease.
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DOI：
10.3390/ijms22126626
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发表时间：
2021-06-21
影响因子：
5.6
通讯作者：
Nikoloudaki G
中科院分区：
文献类型：
--
作者：
Nikoloudaki G
基质细胞蛋白 (MCP) 被定义为细胞外基质 (ECM) 相关蛋白，是微环境信号的重要调节剂和整合剂，有助于 ECM 信号传导的动态特性。人们越来越了解基质细胞蛋白在控制组织发育的细胞过程以及疾病发病机制中的作用。在这篇综述中，介绍了不同 MP 家族成员（骨膜素、CCN、TSP、SIBLING 等）的表达和功能，特别是与颅面发育和口面组织（包括骨、牙龈、口腔粘膜、腭和牙髓）维护相关的表达和功能。正如将要讨论的，每个 MP 家族成员已被证明在口面部和牙齿组织的发育、组织稳态、伤口愈合、病理学和肿瘤发生中具有非冗余的作用。
Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins that are important regulators and integrators of microenvironmental signals, contributing to the dynamic nature of ECM signalling. There is a growing understanding of the role of matricellular proteins in cellular processes governing tissue development as well as in disease pathogenesis. In this review, the expression and functions of different MP family members (periostin, CCNs, TSPs, SIBLINGs and others) are presented, specifically in relation to craniofacial development and the maintenance of orofacial tissues, including bone, gingiva, oral mucosa, palate and the dental pulp. As will be discussed, each MP family member has been shown to have non-redundant roles in development, tissue homeostasis, wound healing, pathology and tumorigenesis of orofacial and dental tissues.
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影响因子：
11.2
作者：
Chang, Cheng-Chi;Hsu, Wen-Hao;Yang, Muh-Hwa
通讯作者：
Yang, Muh-Hwa
影响因子：
4.8
作者：
Black, Samuel A., Jr.;Palamakumbura, Amitha H.;Trackman, Philip C.
通讯作者：
Trackman, Philip C.
影响因子：
1.9
作者：
Baba, O;Qin, CL;Butler, WT
通讯作者：
Butler, WT
影响因子：
7.8
作者：
BORNSTEIN, P
通讯作者：
BORNSTEIN, P
影响因子：
--
作者：
Aquino G;Sabatino R;Cantile M;Aversa C;Ionna F;Botti G;La Mantia E;Collina F;Malzone G;Pannone G;Losito NS;Franco R;Longo F
通讯作者：
Longo F