Estimation of the orientation distribution function from diffusional kurtosis imaging.

Estimation of the orientation distribution function from diffusional kurtosis imaging.
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从扩散峰度成像中估计方向分布函数。

DOI:
10.1002/mrm.21725
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发表时间:
2008-10
影响因子:
3.3
通讯作者:
Helpern, Joseph A.
Helpern, Joseph A.
中科院分区:
医学3区
文献类型:
--
作者:
Lazar, Mariana;Jensen, Jens H.;Xuan, Liang;Helpern, Joseph A.

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方向分布函数(ODF)用于描述大脑和其他生物组织中具有复杂纤维结构的区域中多峰扩散的方向性。本文提出了扩散峰度成像(DKI)中水扩散ODF的近似值。DKI仅需要相对有限数量的弥散测量,对于脑,B值不高于2500 s/mm 2。基于DKI的ODF近似被分解为分别表示高斯和非高斯(NG)扩散贡献的两个分量。多个纤维配置的模拟表明,总和NG-ODF都能够解决组件纤维的取向,与NG-ODF是最敏感的剖析纤维的方向。体内脑成像数据获得的方向图显示了复杂解剖结构的脑区域中的多个纤维成分。结果似乎与已知的白色物质结构一致。
The Orientation Distribution Function (ODF) is used to describe the directionality of multimodal diffusion in regions with complex fiber architecture present in brain and other biological tissues. In this paper, an approximation for the ODF of water diffusion from diffusional kurtosis imaging (DKI) is presented. DKI requires only a relatively limited number of diffusion measurements and, for the brain, b values no higher than 2500 s/mm2. The DKI-based ODF approximation is decomposed into two components representing the Gaussian and non-Gaussian (NG) diffusion contributions, respectively. Simulations of multiple fiber configurations show that both the total and the NG-ODF are able to resolve the orientations of the component fibers, with the NG-ODF being the most sensitive to profiling the fibers’ directions. Orientation maps obtained for in-vivo brain imaging data demonstrate multiple fiber components in brain regions with complex anatomy. The results appear to be in agreement with known white matter architecture.
DOI: 10.1016/s0896-6273(03)00758-x
发表时间: 2003-12-04
期刊: NEURON
影响因子: 16.2
作者:
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