Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory.
Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory.
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DOI：
10.1038/nn.2773
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发表时间：
2011-05
影响因子：
25
通讯作者：
Gazzaley, Adam
中科院分区：
文献类型：
--
作者：
Zanto, Theodore P.;Rubens, Michael T.;Thangavel, Arul;Gazzaley, Adam
选择性注意过滤信息，以限制工作记忆中编码和维护的内容。尽管前额叶皮质(PFC)是选择性注意力和工作记忆的中枢，但连接这些认知能力的潜在神经过程仍然难以捉摸。使用功能磁共振成像来引导人类脑电记录的重复经颅磁刺激，我们在参与者执行选择性注意、延迟识别任务之前，扰乱了额叶下交界处的PFC功能。这导致了编码早期后脑皮层活动自上而下的调节减弱，这预示着工作记忆的准确性随后会降低。前后脑功能连通性更强的参与者表现出更大的干扰效应。数据进一步表明，宽的阿尔法频段(7-14赫兹)的相干性有助于这种长距离的自上而下的调制。这些结果建立了由前额叶皮质介导的自上而下的调制，作为早期注意过程和随后的记忆表现之间的因果联系。
Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imaging to guide repetitive transcranial magnetic stimulation with electroencephalographic recordings in humans, we perturbed PFC function at the inferior frontal junction prior to participants performing a selective-attention, delayed-recognition task. This resulted in diminished top-down modulation of activity in posterior cortex during early encoding stages, which predicted a subsequent decrement in working memory accuracy. Participants with stronger fronto-posterior functional connectivity displayed greater disruptive effects. Data further suggested that broad alpha band (7–14 Hz) phase coherence subserved this long distance top-down modulation. The results establish top-down modulation mediated by the prefrontal cortex as a causal link between early attentional processes and subsequent memory performance.
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