fMRI brain activation changes following treatment of a first bipolar manic episode.
fMRI brain activation changes following treatment of a first bipolar manic episode.
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DOI：
10.1111/bdi.12426
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发表时间：
2016-09
影响因子：
5.4
通讯作者：
Adler CM
中科院分区：
文献类型：
--
作者：
Strakowski SM;Fleck DE;Welge J;Eliassen JC;Norris M;Durling M;Komoroski RA;Chu WJ;Weber W;Dudley JA;Blom TJ;Stover A;Klein C;Strawn JR;DelBello MP;Lee JH;Adler CM
在这项研究中，我们测试了这样的假设，即通过治疗，首发躁狂症患者的功能磁共振成像(FMRI)区域脑激活将恢复正常，即与健康受试者的差异将随着时间的推移而缩小，并将与临床缓解状态相关，潜在地识别神经解剖学治疗反应标记物。42名患有双相I型障碍的参与者在他们的第一次躁狂发作中被招募，伪随机接受开放标签锂或奎硫平治疗，并跟踪观察8周。在基线，然后在治疗一周和八周后进行功能磁共振扫描，同时参与者在情绪分心的情况下进行连续的操作任务。健康的参与者在相同的时间间隔接受功能磁共振扫描。前额叶情绪网络中特定的感兴趣区(ROI)激活被评估为治疗反应的潜在衡量标准。使用探索性因素分析减少ROI数据，确定了与人类情绪调节的功能解剖模型在组织上一致的五个因素，在该人群中复制了先前的因素分析。患有双相情感障碍的参与者中，有一半在第8周时得到缓解，而另一半则没有得到缓解。分析表明，在总体上，在双相情感障碍组中，治疗导致大脑区域对健康受试者价值的激活减少。然而，在双相情感障碍的受试者中，观察到在皮质下因子和杏仁核因子方面有缓解或没有缓解的受试者之间的激活变化存在差异。这些发现为首发双相情感障碍的潜在神经解剖学治疗反应标记物提供了证据。
In this study, we tested the hypothesis that, with treatment, functional magnetic resonance imaging (fMRI) regional brain activation in first-episode mania would normalize, i.e., differences from health subjects would diminish over time, and would be associated with clinical remission status, potentially identifying neuroanatomic treatment response markers. Forty-two participants with bipolar I disorder were recruited during their first manic episode, pseudo-randomized to open-label lithium or quetiapine, and followed for eight weeks. fMRI scans were obtained at baseline and then after one and eight weeks of treatment, while participants performed a continuous performance task with emotional distracters. Healthy participants received fMRI scans at these same intervals. Specific region-of-interest (ROI) activations within prefrontal emotional networks were assessed as potential measures of treatment response. ROI data were reduced using exploratory factor analysis, which identified five factors that were organizationally consistent with functional anatomic models of human emotion modulation, replicating previous factor analyses in this population. One-half of the participants with bipolar disorder achieved remission by Week 8 and were contrasted with the other one-half that did not. Analyses demonstrated that, in the bipolar disorder group in general, treatment led to decreases in activation across brain regions toward healthy subject values. However, differences in activation changes were observed between subjects with bipolar disorder who did or did not achieve remission in subcortical and amygdala factors. These findings provide evidence for potential neuroanatomic treatment response markers in first-episode bipolar disorder.
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影响因子：
11.3
作者：
Schneider MR;Klein CC;Weber W;Bitter SM;Elliott KB;Strakowski SM;Adler CM;DelBello MP
通讯作者：
DelBello MP
在未经药物的躁郁症抑郁症，正肌和躁狂症中面部情绪加工过程中的神经激活。
影响因子：
10.6
作者：
Hulvershorn, Leslie A.;Karne, Harish;Gunn, Abigail D.;Hartwick, Sarah L.;Wang, Yang;Hummer, Tom A.;Anand, Amit
通讯作者：
Anand, Amit
影响因子：
5.4
作者：
Chang, Kiki D.;Wagner, Christopher;Reiss, Allan
通讯作者：
Reiss, Allan
影响因子：
3.2
作者：
Lane, RD;Reiman, EM;Schwartz, GE
通讯作者：
Schwartz, GE
影响因子：
3.4
作者：
Passarotti, Alessandra M.;Sweeney, John A.;Pavuluri, Mani N.
通讯作者：
Pavuluri, Mani N.