Neural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania.
Neural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania.
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在未经药物的躁郁症抑郁症，正肌和躁狂症中面部情绪加工过程中的神经激活。
DOI：
10.1016/j.biopsych.2011.10.038
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发表时间：
2012-04-01
影响因子：
10.6
通讯作者：
Anand, Amit
中科院分区：
文献类型：
--
作者：
Hulvershorn, Leslie A.;Karne, Harish;Gunn, Abigail D.;Hartwick, Sarah L.;Wang, Yang;Hummer, Tom A.;Anand, Amit
研究纳入双相情感障碍（BP）的所有阶段的直接比较，需要阐明双相情感障碍的病理生理学。然而，区分双相情感状态的功能神经影像学研究很少，并产生了不一致的结果。招募了105名未经药物治疗的成年人：30名当前双相抑郁症（BPD）患者，30名当前双相轻躁狂或躁狂（BPM）患者，15名双相情感正常（BPE）患者和30名健康对照受试者（HC）。所有受试者均使用结构化临床访谈诊断为DSM-IV BP（I型或II型）。各组的年龄和性别比例匹配。在3 T功能磁共振成像实验中，受试者完成了负面面部情绪匹配任务。与HC相比，双极正常和BPD组在对消极面孔的反应中表现出杏仁核激活增加;然而，在BPM组中，没有看到这种增加。相反地，BPE和BPM组相对于HC在小脑延髓中的激活增加，但在BPD组中，未观察到这种效应。与HC相比，所有三个BP组的壳核活化均增加。在皮质区，BPM组表现出减少左外侧眶额皮质激活与BPE和HC相比，增加背侧前扣带回皮质激活与BPD组相比，增加背外侧前额叶皮质激活与所有其他组相比。在一个大样本的未经药物治疗的成年人在BP情绪状态下的负面面部情绪处理中，观察到皮质边缘激活的状态和特质相关异常。
Studies incorporating direct comparisons across all phases of bipolar (BP) disorder are needed to elucidate the pathophysiology of bipolar disorder. However, functional neuroimaging studies that differentiate bipolar mood states from each other and from healthy subjects are few and have yielded inconsistent findings. One hundred five unmedicated adults were recruited: 30 with current bipolar depression (BPD), 30 with current bipolar hypomania or mania (BPM), 15 bipolar euthymic (BPE), and 30 healthy control subjects (HC). All subjects were diagnosed with DSM-IV BP (type I or II) using a structured clinical interview. Groups were age- and gender-ratio matched. In 3T functional magnetic resonance imaging experiments, subjects completed a negative facial emotion matching task. Bipolar euthymic and BPD groups exhibited increased amygdala activation compared with HCs in response to the negative faces; however, in the BPM group, this increase was not seen. Conversely, both BPE and BPM groups had increased activation in the insula relative to HCs, but in the BPD group, this effect was not seen. All three BP groups exhibited increased activation of the putamen compared with HCs. In the cortical areas, the BPM group exhibited decreased left lateral orbitofrontal cortex activation compared with both BPEs and HCs, increased dorsal anterior cingulate cortex activation compared with the BPD group, and increased dorsolateral prefrontal cortical activation compared with all other groups. Both state- and trait-related abnormalities in corticolimbic activation were seen in response to the negative facial emotion processing in a large sample of unmedicated adults across BP mood states.
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影响因子：
--
作者：
Blumberg, HP;Leung, HC;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
5.7
作者：
Hariri, AR;Tessitore, A;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
2.4
作者：
Barbas H;Saha S;Rempel-Clower N;Ghashghaei T
通讯作者：
Ghashghaei T
影响因子：
10.6
作者：
Almeida, Jorge R. C.;Versace, Amelia;Hassel, Stefanie;Kupfer, David J.;Phillips, Mary L.
通讯作者：
Phillips, Mary L.
影响因子：
5.4
作者：
Altshuler L;Bookheimer S;Townsend J;Proenza MA;Sabb F;Mintz J;Cohen MS
通讯作者：
Cohen MS