The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma.
The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma.
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DOI：
10.1016/j.jaci.2009.02.021
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发表时间：
2009-05
影响因子：
14.2
通讯作者：
Hartert, Tina V.
中科院分区：
文献类型：
--
作者：
Carroll, Kecia N.;Wu, Pingsheng;Gebretsadik, Tebeb;Griffin, Marie R.;Dupont, William D.;Mitchel, Edward F.;Hartert, Tina V.
关键词：
Infants hospitalized for bronchiolitis have a high rate of early childhood asthma. It is not known whether bronchiolitis severity correlates with the risk of early childhood asthma or with asthma-specific morbidity. To determine whether a dose-response relationship exists between severity of infant bronchiolitis and both the odds of developing early childhood asthma and asthma-specific morbidity. We conducted a population-based retrospective birth cohort study of term, healthy infants born 1995-2000 and enrolled in a statewide Medicaid program. We defined bronchiolitis severity by categorizing infants into mutually exclusive groups based on most advanced level of healthcare for bronchiolitis. Healthcare visits, asthma-specific medications, and demographics were identified entirely from Medicaid and linked vital records files. Asthma was ascertained between 4-5.5 years, and one-year asthma morbidity (hospitalization, emergency department visit, or oral corticosteroid course) was determined between 4.5-5.5 years, among children with prevalent asthma. Among 90,341 children, 18% had an infant bronchiolitis visit, and these infants contributed to 31% of early childhood asthma diagnoses. Relative to children with no infant bronchiolitis visit, the adjusted odds ratios for asthma were 1.86 [95% confidence intervals 1.74-1.99], 2.41 (2.21-2.62) and 2.82 (2.61-3.03) in the Outpatient, Emergency Department, and Hospitalization groups respectively. Children hospitalized with bronchiolitis during infancy had increased early childhood asthma morbidity compared with children with no bronchiolitis visit. To our knowledge, this is the first study to demonstrate the dose-response relationship between severity of infant bronchiolitis and the increased odds of both developing early childhood asthma and experiencing asthma-specific morbidity.
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DOI：
10.1164/rccm.200210-1148oc
发表时间：
2003-09-15
影响因子：
24.7
作者：
Legg, JP;Hussain, IR;Warner, JO
通讯作者：
Warner, JO
影响因子：
5.2
作者：
MURRAY, M;WEBB, MSC;MILNER, AD
通讯作者：
MILNER, AD
在挪威阿克斯胡斯县，婴儿期急性细支气管炎是喘息的危险因素，导致肺功能下降七年。
影响因子：
2.4
作者：
Fjaerli, Hans-Olav;Farstad, Teresa;Rod, Gisle;Ufert, Gunn Kristin;Gulbrandsen, Pal;Nakstad, Britt
通讯作者：
Nakstad, Britt
影响因子：
8
作者：
Carroll, Kecia N.;Gebretsadik, Tebeb;Hartert, Tina V.
通讯作者：
Hartert, Tina V.
影响因子：
5.6
作者：
Dombkowski, Kevin J.;Leung, Sonia W.;Gurney, James G.
通讯作者：
Gurney, James G.