Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases.
Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases.
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胸腺基质细胞生成素在皮肤免疫介导疾病中的作用
DOI：
10.3389/fimmu.2021.698522
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zuo YG
中科院分区：
文献类型：
--
作者：
Wang SH;Zuo YG
胸腺基质淋巴细胞生成素（TSLP）最初被证明在调节各种过敏性疾病（如特应性皮炎、食物过敏和哮喘）的炎症反应中至关重要。尽管 TSLP 的两种亚型（短型和长型）已在人体组织中得到证实，但长型 TSLP (lfTSLP) 与过敏和皮肤免疫介导疾病的发病机制密切相关。 lfTSLP 的免疫调节活性差异很大，可驱动 T 辅助 (Th) 细胞极化 Th2 和 Th17 免疫反应并诱发瘙痒。此外，lfTSLP与皮肤纤维化、表皮增生、血管生成和稳态耐受调节密切相关。本综述强调了 lfTSLP 在皮肤免疫介导疾病（特应性皮炎、牛皮癣、大疱性类天疱疮、系统性硬化症、慢性自发性荨麻疹、白塞病、白癜风、红斑痤疮、系统性红斑狼疮和斑秃）中的实验和临床研究的重大进展。我们还对细胞因子 TSLP 在各种病理生理条件下的多效性特性提供了独到的见解，对未来免疫介导的皮肤病的 TSLP 靶向治疗具有重要的临床意义。
Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as atopic dermatitis, food allergy, and asthma). Although two isoforms (short form and long form) of TSLP have been demonstrated in human tissues, the long form of TSLP (lfTSLP) is strongly implicated in the pathogenesis of allergies and cutaneous immune-mediated diseases. The immunomodulatory activity of lfTSLP varies widely, driving T helper (Th) cells polarizing Th2 and Th17 immune responses and inducing itch. Moreover, lfTSLP is closely associated with skin fibrosis, epidermal hyperplasia, angiogenesis, and homeostatic tolerogenic regulations. This review highlights significant progress from experimental and clinical studies on lfTSLP in cutaneous immune-mediated diseases (atopic dermatitis, psoriasis, bullous pemphigoid, systemic sclerosis, chronic spontaneous urticaria, Behçet’s disease, vitiligo, rosacea, systemic lupus erythematosus, and alopecia areata). We also offer original insights into the pleiotropic properties of the cytokine TSLP in various pathophysiological conditions, with significant clinical implications of TSLP-targeted therapies for immune-mediated skin diseases in the future.
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DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allakhverdi Z;Comeau MR;Jessup HK;Yoon BR;Brewer A;Chartier S;Paquette N;Ziegler SF;Sarfati M;Delespesse G
通讯作者：
Delespesse G
影响因子：
50.3
作者：
Demehri, Shadmehr;Turkoz, Ahu;Kopan, Raphael
通讯作者：
Kopan, Raphael
影响因子：
3.6
作者：
Arai, Iwao;Tsuji, Minoru;Saito, Saburo
通讯作者：
Saito, Saburo
影响因子：
3.6
作者：
Elmasry, Maha Fathy;Nagui, Noha Abdel Rehim;El Darbi, Reem
通讯作者：
El Darbi, Reem
影响因子：
10.9
作者：
Chang, Joshua;Mitra, Nandita;Margolis, David J.
通讯作者：
Margolis, David J.