Electrospun Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/Graphene Oxide Scaffold: Enhanced Properties and Promoted in Vivo Bone Repair in Rats.
Electrospun Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/Graphene Oxide Scaffold: Enhanced Properties and Promoted in Vivo Bone Repair in Rats.
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电纺聚（3-羟基丁酸酯-co-4-羟基丁酸酯）/氧化石墨烯支架：增强性能并促进大鼠体内骨修复。
DOI：
10.1021/acsami.7b14267
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Lin Yunfeng
中科院分区：
文献类型：
--
作者：
Zhou Tengfei;Li Guo;Lin Shiyu;Tian Taoran;Ma Quanquan;Zhang Qi;Shi Sirong;Xue Changyue;Ma Wenjuan;Cai Xiaoxiao;Lin Yunfeng
骨组织工程作为实现组织再生的有利技术而出现。它的支架必须具有优异的生物力学性能，而裸聚合物的性能较差。迫切需要开发具有高成骨能力的新型生物材料。在本研究中，成功制备并表征了电纺聚（3-羟基丁酸酯-co-4-羟基丁酸酯）/氧化石墨烯（P34HB/GO）纳米纤维支架。研究了 GO 含量对支架形态、生物力学特性和细胞行为的影响。 GO 减少了纤维直径，增强了支架的孔隙率、亲水性、机械性能、细胞性能和成骨分化。在大鼠临界大小颅骨缺损的体内骨再生中，P34HB/GO 优于 P34HB。我们相信这项研究是第一个评估静电纺丝 P34HB/GO 支架体内骨修复能力的研究。 P34HB/GO支架具有简便的制造工艺、良好的多孔结构、增强的生物力学性能和快速的成骨能力，在骨组织工程应用中具有实际潜力。
Bone tissue engineering emerges as an advantageous technique to achieve tissue regeneration. Its scaffolds must present excellent biomechanical properties, where bare polymers poorly perform. Development of new biomaterials with high osteogenic capacity is urgently pursued. In this study, an electrospun poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/graphene oxide (P34HB/GO) nanofibrous scaffold is successfully fabricated and characterized. The effects of GO amount on scaffold morphology, biomechanical properties, and cellular behaviors are investigated. GO reduces the fiber diameter and enhances porosity, hydrophilicity, mechanical properties, cellular performance, and osteogenic differentiation of scaffolds. P34HB/GO triumphs over P34HB in in vivo bone regeneration in critical-sized calvarial defect of rats. We believe that this study is the first to evaluate the capability of in vivo bone repair of electrospun P34HB/GO scaffold. With facile fabrication process, favorable porous structures, enhanced biomechanical properties, and fast osteogenic capability, P34HB/GO scaffold holds practical potentials for bone tissue engineering application.
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