Viscoelasticity measured by shear wave elastography in a rat model of nonalcoholic fatty liver disease: comparison with dynamic mechanical analysis.
Viscoelasticity measured by shear wave elastography in a rat model of nonalcoholic fatty liver disease: comparison with dynamic mechanical analysis.
复制标题
非酒精性脂肪肝大鼠模型中剪切波弹性成像测量的粘弹性：与动态力学分析的比较
DOI：
10.1186/s12938-021-00879-3
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发表时间：
2021-05-03
影响因子：
3.9
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Pi Z;Wang M;Lin H;Guo Y;Chen S;Diao X;Xia H;Liu G;Zeng J;Zhang X;Chen X
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by elastography technology has mainly focused on steatosis with fibrosis or non-alcoholic steatohepatitis (NASH), while steatosis without fibrosis has been poorly studied. Moreover, the relationship between liver viscoelasticity and steatosis grade is not clear. In this study, we evaluated the degree of liver steatosis in a simple steatosis rat model using shear wave elastography (SWE). The viscoelasticity values of 69 rats with hepatic steatosis were measured quantitatively by SWE in vivo and validated by a dynamic mechanical analysis (DMA) test. Pathological sections were used to determine the steatosis grade for each rat. The results showed that the elasticity values µ obtained by the two methods followed the same trend, and µ is significantly correlated with liver steatosis. The Pearson’s correlation coefficients indicate that obtained by SWE is positively linear correlated with DMA (r = 0.628, p = 7.85 × 10–9). However, the viscosity values obtained by SWE were relatively independent of those obtained by DMA with a correlation coefficient of − 0.01. The combined Voigt elasticity measurements have high validity in the prediction of steatosis (S0 vs. S1–S4), with an AUROC of 0.755 (95% CI 0.6175–0.8925, p < 0.01) and the optimal cutoff value was 2.08 kPa with a sensitivity of 78% and specificity of 63%. SWE might have the feasibility to be introduced as an auxiliary technique for NAFLD patients in clinical settings. However, the viscosity results measured by SWE and DMA are significantly different, because the two methods work in different frequency bands.
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影响因子：
6.3
作者：
Ebinuma, Hirotoshi;Saito, Hidetsugu;Hibi, Toshifumi
通讯作者：
Hibi, Toshifumi
影响因子：
2.4
作者：
OESTREICHER, HL
通讯作者：
OESTREICHER, HL
影响因子：
1.8
作者：
Ogawa, Saori;Moriyasu, Fuminori;Sugimoto, Katsutoshi
通讯作者：
Sugimoto, Katsutoshi
影响因子：
2.9
作者：
Ferraioli, Giovanna;Filice, Carlo;Kudo, Masatoshi
通讯作者：
Kudo, Masatoshi
影响因子：
2.1
作者：
Motosugi, Utaroh;Ichikawa, Tomoaki;Araki, Tsutomu
通讯作者：
Araki, Tsutomu