Fibroblast growth factor signaling in mammalian tooth development.
Fibroblast growth factor signaling in mammalian tooth development.
复制标题
哺乳动物牙齿发育中的成纤维细胞生长因子信号传导。
DOI：
10.1007/s10266-013-0142-1
复制
发表时间：
2014-01
期刊：
影响因子：
2.5
通讯作者：
Klein, Ophir D.
中科院分区：
文献类型：
--
作者：
Li, Chun-Ying;Prochazka, Jan;Goodwin, Alice F.;Klein, Ophir D.
在这篇综述中，我们讨论了成纤维细胞生长因子（FGF）信号在哺乳动物牙齿发育中的核心作用。FGF家族由22个成员组成，其中大多数与四种不同的受体酪氨酸激酶结合，这些受体酪氨酸激酶进而通过细胞内蛋白质级联传递信号。这种信号传导调节许多细胞过程，包括增殖、分化、细胞粘附和细胞移动性。FGF信号首先在牙齿发育的起始阶段在假定的牙上皮中变得重要，随后，它控制牙上皮内陷到下面的间充质中。后来，FGF在牙齿形状形成和成釉细胞和成牙本质细胞的分化中，以及在为持续生长的小鼠切牙提供燃料的干细胞生态位的发育和稳态中至关重要。此外，FGF信号传导在人类牙齿中是至关重要的，因为编码FGF配体或受体的基因突变导致几种先天性综合征，其特征在于牙齿数量、形态或釉质结构的改变。FGF信号在小鼠和人类牙齿发育中的平行作用证明了FGF信号在哺乳动物牙齿发生中的保守重要性。
In this review, we discuss the central role of fibroblast growth factor (FGF) signalling in mammalian tooth development. The FGF family consists of 22 members, most of which bind to four different receptor tyrosine kinases, which in turn signal through a cascade of intracellular proteins. This signaling regulates a number of cellular processes, including proliferation, differentiation, cell adhesion and cell mobility. FGF signaling first becomes important in the presumptive dental epithelium at the initiation stage of tooth development, and subsequently, it controls the invagination of the dental epithelium into the underlying mesenchyme. Later, FGFs are critical in tooth shape formation and differentiation of ameloblasts and odontoblasts, as well as in the development and homeostasis of the stem cell niche that fuels the continuously growing mouse incisor. In addition, FGF signaling is critical in human teeth, as mutations in genes encoding FGF ligands or receptors result in several congenital syndromes characterized by alterations in tooth number, morphology or enamel structure. The parallel roles of FGF signaling in mouse and human tooth development demonstrate the conserved importance of FGF signaling in mammalian odontogenesis.
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DOI：
10.1002/jez.b.21254
发表时间：
2009-07-15
影响因子：
2.2
作者：
Boran, Tomas;Peterkova, Renata;Lesot, Herve;Lyons, David B.;Peterka, Miroslav;Klein, Ophir D.
通讯作者：
Klein, Ophir D.
影响因子：
5.2
作者：
Alsmadi, Osama;Meyer, Brian F.;Al-Sayed, MoeenAldeen
通讯作者：
Al-Sayed, MoeenAldeen
影响因子：
2.7
作者：
Christen, B;Slack, JMW
通讯作者：
Slack, JMW
影响因子：
3.5
作者：
AVIVI, A;YAYON, A;GIVOL, D
通讯作者：
GIVOL, D
影响因子：
64.5
作者：
HABETS, GGM;SCHOLTES, EHM;COLLARD, JG
通讯作者：
COLLARD, JG