Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents.
Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents.
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DOI：
10.1038/emi.2013.77
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发表时间：
2013-11
影响因子：
13.2
通讯作者：
Block, Timothy
中科院分区：
文献类型：
--
作者：
Chang, Jinhong;Guo, Ju-Tao;Du, Yanming;Block, Timothy
埃博拉病毒和马尔堡病毒是丝状病毒科的成员，是致命的出血热疾病的病原体。埃博拉病毒和马尔堡出血热的临床症状很难区分，目前还没有针对这两种病毒的特异性抗病毒疗法。因此，一种对这两种药物都安全有效的药物将是一个巨大的突破。我们和其他人已经表明，许多包膜病毒（包括丝状病毒）的糖蛋白折叠比大多数宿主糖蛋白更依赖于蛋白折叠的钙连接蛋白途径。抑制这一途径的药物有望选择性地抗病毒。事实上，正如我们在这篇综述中所总结的，作为宿主内质网α-葡萄糖苷酶I和II的竞争性抑制剂的亚胺糖，已经显示出对许多包膜病毒（包括丝状病毒）具有抗病毒活性，其中内质网α-葡萄糖苷酶I和II是处理新生糖蛋白上的N-聚糖，从而抑制钙连接蛋白与新生糖蛋白结合的酶。在这篇综述中，我们描述了用于对抗丝状病毒的亚氨基糖的发展状况，并解释了其抗病毒活性的基础以及局限性。
Ebola virus and Marburg virus are members of the family of Filoviridae and are etiological agents of a deadly hemorrhagic fever disease. The clinical symptoms of Ebola and Marburg hemorrhagic fevers are difficult to distinguish and there are currently no specific antiviral therapies against either of the viruses. Therefore, a drug that is safe and effective against both would be an enormous breakthrough. We and others have shown that the folding of the glycoproteins of many enveloped viruses, including the filoviruses, is far more dependent upon the calnexin pathway of protein folding than are most host glycoproteins. Drugs that inhibit this pathway would be expected to be selectively antiviral. Indeed, as we summarize in this review, imino sugars that are competitive inhibitors of the host endoplasmic reticular α-glucosidases I and II, which are enzymes that process N-glycan on nascent glycoproteins and thereby inhibit calnexin binding to the nascent glycoproteins, have been shown to have antiviral activity against a number of enveloped viruses including filoviruses. In this review, we describe the state of development of imino sugars for use against the filoviruses, and provide an explanation for the basis of their antiviral activity as well as limitations.
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DOI：
10.1038/nrmicro975
发表时间：
2004-09
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
De Clercq E
通讯作者：
De Clercq E
影响因子：
64.8
作者：
Cote, Marceline;Misasi, John;Ren, Tao;Bruchez, Anna;Lee, Kyungae;Filone, Claire Marie;Hensley, Lisa;Li, Qi;Ory, Daniel;Chandran, Kartik;Cunningham, James
通讯作者：
Cunningham, James
影响因子：
3.5
作者：
Bijvoet, AGA;van de Kamp, EHM;van der Ploeg, AT
通讯作者：
van der Ploeg, AT
DOI：
10.1006/bbrc.1995.1333
发表时间：
1995-03-08
影响因子：
3.1
作者：
AHMED, SP;NASH, RJ;TYMS, AS
通讯作者：
TYMS, AS
影响因子：
5.4
作者：
Courageot, MP;Frenkiel, MP;Desprès, P
通讯作者：
Desprès, P