Latent trajectories of anxiety and depressive symptoms among adults in early treatment for nonmedical opioid use.
Latent trajectories of anxiety and depressive symptoms among adults in early treatment for nonmedical opioid use.
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DOI：
10.1016/j.jad.2021.12.004
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发表时间：
2022-02-15
影响因子：
6.6
通讯作者：
Huhn AS
中科院分区：
文献类型：
--
作者：
Ellis JD;Rabinowitz JA;Wells J;Liu F;Finan PH;Stein MD;Ii DGA;Hobelmann GJ;Huhn AS
了解早期阿片类药物使用障碍 (OUD) 治疗中焦虑和抑郁症状的过程可能有助于促进积极的早期治疗反应并减少治疗流失。从 86 个成瘾治疗机构中确定了接受非医疗阿片类药物使用治疗的人员。生长混合模型用于确定治疗第一个月期间在摄入时筛查出抑郁（N = 3016）和/或焦虑（N = 2779）阳性的个体的焦虑和抑郁症状轨迹。三类解决方案最适合焦虑症状的数据，包括以下轨迹：1）持续的中度至重度焦虑症状，2）缓解严重的焦虑症状，3）持续的轻度至轻度焦虑症状。同样，三类解决方案最适合抑郁症状的数据，并包括以下特征的轨迹：1) 持续的中度至重度抑郁症状，2) 持续的中度抑郁症状，3) 轻度/缓解抑郁症状。女性和过去一个月大量同时使用苯二氮卓类药物预示着持续的中度至重度焦虑和抑郁症状。没有收集有关物质使用的细粒度信息。结果可能无法推广到在专业成瘾诊所之外接受治疗的个人。对早期治疗中焦虑和抑郁症状轨迹的分析表明，接受阿片类药物使用治疗的一部分人经历了持续且显着的焦虑和抑郁症状，而其他人则经历了症状缓解。针对风险最大的个体（例如报告阿片类药物/苯二氮卓类药物同时使用的女性和个体）而设计的干预措施可能有助于改善早期 OUD 治疗中的心理健康症状。
Understanding the course of anxiety and depressive symptoms in early opioid use disorder (OUD) treatment may inform efforts to promote positive early treatment response and reduce treatment attrition. Persons in treatment for nonmedical opioid use were identified from 86 addiction treatment facilities. Growth mixture modeling was used to identify trajectories of anxiety and depression symptoms during the first month of treatment among individuals who screened positive for depression (N=3016) and/or anxiety (N=2779) at intake. A three-class solution best fit the data for anxiety symptoms and included the following trajectories: 1) persistent moderate-to-severe anxiety symptoms, 2) remitting severe anxiety symptoms, and 3) persistent minimal-to-mild anxiety symptoms. Similarly, a three-class solution best fit the data for depressive symptoms and included trajectories characterized by 1) persistent moderate-to-severe depressive symptoms, 2) persistent moderate depressive symptoms, and 3) mild/remitting depressive symptoms. Persistent moderate-to-severe anxiety and depressive symptoms were predicted by female gender and heavy past-month benzodiazepine co-use. Fine grained-information about substance use was not collected. Results may not be generalizable to individuals receiving treatment outside of specialty addiction clinics. Analysis of anxiety and depression symptom trajectories in early treatment suggest that a subset of individuals entering treatment for opioid use experienced persistent and significant anxiety and depressive symptoms, whereas others experience a remission of symptoms. Interventions designed to target individuals at the greatest risk, such as women and individuals reporting opioid/benzodiazepine co-use, may help improve mental health symptoms in early OUD treatment.
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影响因子：
13.8
作者：
Huhn AS;Hobelmann JG;Strickland JC;Oyler GA;Bergeria CL;Umbricht A;Dunn KE
通讯作者：
Dunn KE
影响因子：
3.9
作者：
Askari, Melanie S.;Martins, Silvia S.;Mauro, Pia M.
通讯作者：
Mauro, Pia M.
DOI：
10.1097/01.jaa.0000742976.14811.36
发表时间：
2021-06-01
影响因子：
1.1
作者：
Mitchell, Michaela;Shee, Kameron;Evans, Matthew
通讯作者：
Evans, Matthew
DOI：
10.1002/cad.20398
发表时间：
2021-01-01
期刊：
DEVELOPMENTAL METHODS 2021
影响因子：
--
作者：
Johnson, Sara K.
通讯作者：
Johnson, Sara K.
影响因子：
6.6
作者：
Bentley KH;Sakurai H;Lowman KL;Rines-Toth L;McKowen J;Pedrelli P;Evins AE;Yule AM
通讯作者：
Yule AM