Functional connectivity of the default mode network and its association with pain networks in irritable bowel patients assessed via lidocaine treatment.
Functional connectivity of the default mode network and its association with pain networks in irritable bowel patients assessed via lidocaine treatment.
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DOI：
10.1016/j.jpain.2013.04.003
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发表时间：
2013-10
期刊：
影响因子：
4
通讯作者：
Robinson, Michael E.
中科院分区：
文献类型：
--
作者：
Letzen, Janelle E.;Craggs, Jason G.;Perlstein, William M.;Price, Donald D.;Robinson, Michael E.
默认模式网络（DMN）是一组涉及被动思维过程的大脑区域，已被提出作为潜在的信息神经标记物，以帮助开发新的治疗方法。然而，DMN的内部连接和它的时间关系（即，功能网络连接）与疼痛相关的神经网络在慢性疼痛条件下知之甚少，是DMN的镇痛效果的敏感性。本研究评估了肠易激综合征患者经直肠利多卡因治疗后，DMN功能连接及其与3种疼痛相关网络的时间相关性的变化。11例肠易激综合征女性患者在2种条件下的功能性磁共振成像期间接受了直肠球囊扩张范例：自然史（即基线）和利多卡因。结果显示，在自然史期间，DMN与疼痛相关区域的连接性增加，并且在利多卡因下DMN结构的网络内连接性增加。此外，有一个显着更大的滞后时间之间的2个疼痛网络，那些参与认知和情感疼痛过程，比较利多卡因的自然历史。这些发现表明：1）DMN可塑性对镇痛作用敏感，2）通过镇痛降低疼痛评分反映DMN连接更类似于无痛个体。研究结果表明，这个网络作为一种方法，了解临床疼痛管理技术的潜在影响。这项研究表明，利多卡因，一种外周镇痛药，显着改变DMN连接，并影响其与疼痛相关网络的关系。这些研究结果表明，DMN，这是假设代表非目标导向的活动，是敏感的镇痛效果，并可能有助于了解疼痛治疗机制。
The default mode network (DMN), a group of brain regions implicated in passive thought processes, has been proposed as a potentially informative neural marker to aid in novel treatment development. However, the DMN’s internal connectivity and its temporal relationship (ie, functional network connectivity) with pain-related neural networks in chronic pain conditions is poorly understood, as is the DMN’s sensitivity to analgesic effects. The current study assessed how DMN functional connectivity and its temporal association with 3 pain-related networks changed after rectal lidocaine treatment in irritable bowel syndrome patients. Eleven females with irritable bowel syndrome underwent a rectal balloon distension paradigm during functional magnetic resonance imaging in 2 conditions: natural history (ie, baseline) and lidocaine. Results showed increased DMN connectivity with pain-related regions during natural history and increased within-network connectivity of DMN structures under lidocaine. Further, there was a significantly greater lag time between 2 of the pain networks, those involved in cognitive and in affective pain processes, comparing lidocaine to natural history. These findings suggest that 1) DMN plasticity is sensitive to analgesic effects, and 2) reduced pain ratings via analgesia reflect DMN connectivity more similar to pain-free individuals. Findings show potential implications of this network as an approach for understanding clinical pain management techniques. This study shows that lidocaine, a peripheral analgesic, significantly altered DMN connectivity and affected its relationship with pain-related networks. These findings suggest that the DMN, which is hypothesized to represent non-goal-oriented activity, is sensitive to analgesic effects and could be useful to understand pain treatment mechanisms.
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