Activation of anterior insula during self-reflection.
Activation of anterior insula during self-reflection.
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DOI：
10.1371/journal.pone.0004618
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Aleman, Andre
中科院分区：
文献类型：
--
作者：
Modinos, Gemma;Ormel, Johan;Aleman, Andre
功能性神经影像学研究表明，额顶叶中线脑区的激活是自我相关过程的核心。然而，尽管一些研究报告了大脑皮层的参与，很少有人注意到这一区域作为“自我”网络的一部分。使用功能性磁共振成像（fMRI），我们的目的是复制和扩展以前的研究扫描对象，同时反映自己的个人素质相比，那些熟人。第三个条件与声明的一般知识被用来控制注意力，语义处理和决策过程。结果显示，任务对大脑活动的影响显著，这与先前的研究结果一致，即两个人的条件都招募了一组共同的内侧前额叶和后部区域，但在内侧前额叶皮层（MPFC）和前扣带皮层（ACC）中发现了自我和他人之间的显著差异。值得注意的是，左前额叶的显著神经激活被观察到与自我反思唯一相关。这些结果为前MPFC和ACC区域的特定招募提供了进一步的证据，并强调了前额叶在自我反思中的作用。由于情绪与提升的内部身体信号密切相关，这可能表明，自我处理过程中可能隐含的情感状态变化的积累可能有助于我们的自我意识。
Functional neuroimaging studies have suggested activation of midline frontoparietal brain regions to be at the core of self-related processes. However, although some studies reported involvement of the insula, little attention has been paid to this region as forming part of the “self”-network. Using functional magnetic resonance imaging (fMRI), we aimed at replicating and extending previous studies by scanning subjects whilst reflecting upon their own personal qualities as compared to those of an acquaintance. A third condition with statements about general knowledge was used to control for attention, semantic processing and decision making processes. The results showed a significant effect of task in brain activity, consistent with previous findings, by which both person conditions recruited a common set of medial prefrontal and posterior regions, yet significant differences between self and other were found in the medial prefrontal cortex (MPFC) and the anterior cingulate cortex (ACC). Notably, significant neural activation in the left anterior insula was observed as uniquely associated with self-reflection. The results provide further evidence for the specific recruitment of anterior MPFC and ACC regions for self-related processing, and highlight a role for the insula in self-reflection. As the insula is closely connected with ascending internal body signals, this may indicate that the accumulation of changes in affective states that might be implied in self-processing may contribute to our sense of self.
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