Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients
Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients
复制标题
早期失明患者内在功能性大脑网络内的动态相互作用减少
DOI：
10.3389/fnins.2019.00268
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发表时间：
2019-03
影响因子：
4.3
通讯作者：
Tian Jie
中科院分区：
文献类型：
--
作者：
Li Xianglin;Wang Ailing;Xu Junhai;Sun Zhenbo;Xia Jikai;Wang Peiyuan;Wang Bin;Zhang Ming;Tian Jie
早期失明（EB）患者的神经影像学研究显示连接或脑网络改变。然而，目前尚不清楚内在大脑网络中的因果关系是如何被破坏的。在我们的研究中，我们使用谱动态因果模型（DCM）来估计20名EB患者和20名健康对照（HC）的静息状态数据的因果相互作用。估计了特定区域的耦合参数，包括默认模式网络（DMN）中的内侧前额叶皮层（mPFC）、后扣带皮层（PCC）和下顶叶（IPC）；突出网络（SN）中的背前扣带皮层（dACC）和双侧前岛叶（AI），以及背侧注意网络（DAN）中的双侧额视野（FEF）和上顶叶（SPL）。统计分析发现，EB患者DMN内所有内源性连接以及mPFC到双侧ipc的连接均明显减少，PCC、lIPC到mPFC、mPFC到PCC的有效连通性增强。对于SN，除固有的右侧AI连接外，EB患者所有显著连接均显著减少。在DAN内，EB组和HC组之间的有效连接明显减少，而只有右SPL到左SPL的连接和左SPL的固有连接显著增强。此外，在EB受试者中发现了更多的有效连接减少，这表明特定区域之间被破坏的因果相互作用是对早期剥夺的代偿性大脑可塑性的反应。
Neuroimaging studies in early blind (EB) patients have shown altered connections or brain networks. However, it remains unclear how the causal relationships are disrupted within intrinsic brain networks. In our study, we used spectral dynamic causal modeling (DCM) to estimate the causal interactions using resting-state data in a group of 20 EB patients and 20 healthy controls (HC). Coupling parameters in specific regions were estimated, including the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), and inferior parietal lobule (IPC) in the default mode network (DMN); dorsal anterior cingulate cortex (dACC) and bilateral anterior insulae (AI) in the salience network (SN), and bilateral frontal eye fields (FEF) and superior parietal lobes (SPL) within the dorsal attention network (DAN). Statistical analyses found that all endogenous connections and the connections from the mPFC to bilateral IPCs in EB patients were significantly reduced within the DMN, and the effective connectivity from the PCC and lIPC to the mPFC, and from the mPFC to the PCC were enhanced. For the SN, all significant connections in EB patients were significantly decreased, except the intrinsic right AI connections. Within the DAN, more significant effective connections were observed to be reduced between the EB and HC groups, while only the connections from the right SPL to the left SPL and the intrinsic connection in the left SPL were significantly enhanced. Furthermore, discovery of more decreased effective connections in the EB subjects suggested that the disrupted causal interactions between specific regions are responsive to the compensatory brain plasticity in early deprivation.
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