The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity.
The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity.
复制标题
DOI：
10.1016/j.cmet.2017.07.020
复制
发表时间：
2017-10-03
期刊：
影响因子：
29
通讯作者：
Oliver G
中科院分区：
文献类型：
--
作者：
Escobedo N;Oliver G
肥胖是代谢和心血管疾病的一个关键风险因素，尽管我们了解调节体重和能量平衡的机制，但某些形式的肥胖的原因仍然是谜。尽管在脂肪代谢和脂质之间建立了良好的联系，并且肠道乳糖在膳食脂肪吸收中起关键作用，但淋巴管系统在脂肪代谢中的功能直到最近才被认识到。众所周知，血管生成与脂肪组织的生长密切相关，因为扩张的脂肪组织需要增加来自血管的营养供应。支持淋巴系统和脂肪组织之间相互作用的结果，以及将淋巴功能与代谢疾病、肥胖和脂肪组织联系起来的结果在过去几年也开始积累。在这里，我们回顾了我们目前的知识的机制，有缺陷的脂肪有助于肥胖和脂肪堆积的小鼠模型，以及我们的理解的脂肪组织的关系。
Obesity is a key risk factor for metabolic and cardiovascular diseases, and although we understand the mechanisms regulating weight and energy balance, the causes of some forms of obesity remain enigmatic. Despite the well-established connections between lymphatics and lipids, and that intestinal lacteals play key roles in dietary fat absorption, the function of the lymphatic vasculature in adipose metabolism has only recently been recognized. It is well established that angiogenesis is tightly associated with the outgrowth of adipose tissue, as expanding adipose tissue requires increased nutrient supply from blood vessels. Results supporting a crosstalk between lymphatics and adipose tissue, and linking lymphatic function with metabolic diseases, obesity and adipose tissue also started to accumulate in the last years. Here we review our current knowledge of the mechanisms by which defective lymphatics contribute to obesity and fat accumulation in mouse models, as well as our understanding of the lymphatics-adipose tissue relationship.
登录
查看更多内容
影响因子：
11.8
作者：
Bazigou, Eleni;Xie, Sherry;Chen, Chun;Weston, Anne;Miura, Naoyuki;Sorokin, Lydia;Adams, Ralf;Muro, Andres F.;Sheppard, Dean;Makinen, Taija
通讯作者：
Makinen, Taija
巨噬细胞的局部扩散有助于与肥胖相关的脂肪组织炎症。
影响因子：
29
作者：
Amano SU;Cohen JL;Vangala P;Tencerova M;Nicoloro SM;Yawe JC;Shen Y;Czech MP;Aouadi M
通讯作者：
Aouadi M
影响因子：
120.1
作者：
Cao, Yihai
通讯作者：
Cao, Yihai
影响因子：
2.8
作者：
BILANCINI, S;LUCCHI, M;ELEUTERI, P
通讯作者：
ELEUTERI, P
DOI：
10.1016/s0735-1097(01)01212-8
发表时间：
2001-05-01
影响因子：
24
作者：
Al Suwaidi, J;Higano, ST;Lerman, A
通讯作者：
Lerman, A