Short-term energy restriction reduces resting energy expenditure in patients with HIV lipodystrophy and hypermetabolism.
Short-term energy restriction reduces resting energy expenditure in patients with HIV lipodystrophy and hypermetabolism.
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短期能量限制可减少 HIV 脂肪营养不良和代谢亢进患者的静息能量消耗。
DOI：
10.1016/j.metabol.2006.10.012
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Horton,TracyJ
中科院分区：
文献类型：
--
作者：
Kosmiski,LisaA;Bessesen,DanielH;Stotz,SarahA;Koeppe,JohnR;Horton,TracyJ
我们以前已经表明，静息能量消耗（REE）增加与艾滋病毒脂肪营养不良的患者。这种高代谢可能是皮下脂肪组织贮库萎缩继发的脂质燃料储存能力不足的结果。因此，能量限制可能能够缓解这种高代谢。为了验证这一假设，我们测量了REE在HIV感染患者脂肪代谢障碍和高代谢，并在HIV感染和健康对照。在正常能量饮食3天后的过夜禁食状态下进行测量，并在类似组成但能量减少50%的饮食3天后再次进行测量。经过3天的能量充足的喂养，与健康对照组相比，患有脂肪营养不良的HIV感染患者的REE显著升高（139.5 ± 1.3 vs 117.2 ± 1.3 kJ/kg瘦体重，P <0.001），与无脂肪代谢障碍的HIV感染者相比，（139.5 ± 13 vs 127.3 ± 1.4 kJ/kg瘦体重，P = 0.06）。此外，能量限制导致HIV脂肪营养不良患者的REE显著下降（P <0.001）。这种饮食操作并没有导致显着减少REE在HIV感染者或健康对照组。这表明，能量摄入和REE可能是唯一耦合在脂肪代谢障碍患者作为一种手段，以消散不能以正常方式存储的能量。更好地理解这种耦合将对体重调节产生重要影响。
We have previously shown that resting energy expenditure (REE) is increased in patients with HIV lipodystrophy. This hypermetabolism could be the result of an inadequate storage capacity for lipid fuel secondary to atrophy of the subcutaneous adipose tissue depot. Therefore, energy restriction may be able to alleviate this hypermetabolism. To test this hypothesis, we measured REE in HIV-infected patients with lipodystrophy and hypermetabolism and in HIV-infected and healthy controls. Measurements were taken during the overnight fasted state after 3 days on a eu-energetic diet and again after 3 days on a diet of similar composition but reduced in energy by 50%. After 3 days of eu-energetic feeding, REE was significantly higher in HIV-infected patients with lipodystrophy compared with healthy controls (139.5 ± 1.3 vs 117.2 ± 1.3 kJ/kg lean body mass, P < .001) and tended to be higher compared with HIV-infected subjects without lipodystrophy (139.5 ± 13 vs 127.3 ± 1.4 kJ/kg lean body mass, P = .06). Furthermore, energy restriction caused a significant decline in REE in patients with HIV lipodystrophy (P < .001). This dietary manipulation did not lead to a significant reduction in REE in either HIV-infected or healthy controls. This suggests that energy intake and REE may be uniquely coupled in patients with lipodystrophy as a means to dissipate energy that cannot be stored in a normal manner. A better understanding of this coupling would have important implications for weight regulation in general.
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影响因子：
16.2
作者：
Haap, M;Siewecke, C;Stumvoll, M
通讯作者：
Stumvoll, M
HIV-1 感染者体内脂肪重新分布综合征：与皮质醇和儿茶酚胺的关系
影响因子：
3.2
作者：
E. Renard;J. Fabre;F. Paris;J. Reynes;J. Bringer
通讯作者：
J. Bringer
DOI：
10.1007/bf00430347
发表时间：
1975
期刊：
Humangenetik
影响因子：
--
作者：
J. Köbberling;B. Willms;R. Kattermann;W. Creutzfeldt
通讯作者：
W. Creutzfeldt
影响因子：
9.8
作者：
ROBBINS, DC;DANFORTH, E;SIMS, EAH
通讯作者：
SIMS, EAH
DOI：
10.1152/ajpendo.00391.2001
发表时间：
2003-02-01
影响因子：
5.1
作者：
Luzi, L;Perseghin, G;Lazzarin, A
通讯作者：
Lazzarin, A