TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes.
TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes.
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DOI：
10.1017/erm.2022.18
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发表时间：
2022-06-10
影响因子：
6.2
通讯作者：
Cheng, Yan-xiang
中科院分区：
文献类型：
--
作者：
Dai, Fang-fang;Hu, Min;Zhang, Yu-wei;Zhu, Rong-hui;Chen, Li-ping;Li, Zhi-dian;Huang, Yan-jie;Hu, Wei;Cheng, Yan-xiang
怀孕是一个复杂的生物过程。胎儿-母体界面的建立和维持是关键事件。蜕膜免疫细胞和炎症细胞因子在胎儿-母体界面中发挥着不可或缺的作用。蜕膜免疫细胞的功能障碍会导致不良妊娠结局。肿瘤坏死因子（TNF）-α是一种常见的炎症细胞因子，在正常妊娠过程的不同阶段发挥着关键作用。然而，TNF-α紊乱与子痫前期（PE）、宫内生长受限（IUGR）、自然流产（SA）、早产等不良妊娠结局之间的关系仍不确定。在这篇综述中，我们全面回顾了 TNF-α 紊乱对病理状况的影响。此外，我们还总结了目前临床研究中使用抗TNF-α药物（英夫利昔单抗、依那西普和阿达木单抗、赛妥珠单抗和戈利木单抗）的不良妊娠结局（PE、IUGR、SA和早产）的报道。总体而言，IUGR、SA和早产是抗TNF-α药物最常见的不良妊娠结局。我们的综述可能为妊娠相关并发症的免疫治疗提供见解，并帮助从业者根据当前证据做出明智的决定。
Pregnancy is a complex biological process. The establishment and maintenance of foetal–maternal interface are pivotal events. Decidual immune cells and inflammatory cytokines play indispensable roles in the foetal–maternal interface. The disfunction of decidual immune cells leads to adverse pregnancy outcome. Tumour necrosis factor (TNF)-α, a common inflammatory cytokine, has critical roles in different stages of normal pregnancy process. However, the relationship between the disorder of TNF-α and adverse pregnancy outcomes, including preeclampsia (PE), intrauterine growth restriction (IUGR), spontaneous abortion (SA), preterm birth and so on, is still indefinite. In this review, we thoroughly reviewed the effect of TNF-α disorder on pathological conditions. Moreover, we summarized the reports about the adverse pregnancy outcomes (PE, IUGR, SA and preterm birth) of using anti-TNF-α drugs (infliximab, etanercept and adalimumab, certolizumab and golimumab) currently in the clinical studies. Overall, IUGR, SA and preterm birth are the most common adverse pregnancy outcomes of anti-TNF-α drugs. Our review may provide insight for the immunological treatment of pregnancy-related complication, and help practitioners make informed decisions based on the current evidences.
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DOI：
10.1084/jem.20130295
发表时间：
2014-01-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cotechini T;Komisarenko M;Sperou A;Macdonald-Goodfellow S;Adams MA;Graham CH
通讯作者：
Graham CH
影响因子：
3.7
作者：
Chambers, Christina D.;Johnson, Diana L.;Jones, Kenneth Lyons
通讯作者：
Jones, Kenneth Lyons
影响因子：
4.1
作者：
Chen R;Qian H;Yuan X;Chen S;Liu Y;Wang B;Shi G
通讯作者：
Shi G
影响因子：
1.3
作者：
Elfayomy, A. K.;Habib, F. A.;Eldomiaty, M. A.
通讯作者：
Eldomiaty, M. A.
影响因子：
13.3
作者：
Clowse, Megan E. B.;Scheuerle, Angela E.;Foerger, Frauke
通讯作者：
Foerger, Frauke