Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila.
Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila.
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DOI：
10.1126/science.1166673
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发表时间：
2009-04-03
期刊：
影响因子：
--
通讯作者：
Cirelli C
中科院分区：
文献类型：
--
作者：
Gilestro GF;Tononi G;Cirelli C
睡眠是普遍的，严格控制的，对认知是必要的。为什么会这样仍然是一个谜，尽管最近的研究表明睡眠、记忆和可塑性之间存在联系。然而，人们对清醒和睡眠如何影响突触知之甚少。利用Western blots和共聚焦显微镜技术，我们发现果蝇中枢突触关键成分的蛋白水平在清醒后高，在睡眠后低。这些变化与行为状态有关，而不是与一天中的时间有关，并且发生在果蝇大脑的所有主要区域。睡眠期间突触标记物的减少是进行性的，睡眠是其下降的必要条件。因此，睡眠可能参与维持被清醒活动改变的突触内稳态。
Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, though recent work suggests a link between sleep, memory, and plasticity. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in Drosophila, we found that protein levels of key components of central synapses were high after waking and low after sleep. These changes were related to behavioral state rather than time of day and occurred in all major areas of the Drosophila brain. The decrease of synaptic markers during sleep was progressive and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities.
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影响因子：
9.8
作者：
Cirelli C;Tononi G
通讯作者：
Tononi G
影响因子：
5.3
作者：
HEISENBERG, M;HEUSIPP, M;WANKE, C
通讯作者：
WANKE, C
影响因子：
64.5
作者：
WOODS, DF;BRYANT, PJ
通讯作者：
BRYANT, PJ
影响因子：
3
作者：
Mehnert, Kerstin I.;Beramendi, Ana;Cantera, Rafael
通讯作者：
Cantera, Rafael
影响因子：
25
作者：
Vyazovskiy, Vladyslav V.;Cirelli, Chiara;Tononi, Giulio
通讯作者：
Tononi, Giulio