Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis.

Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis.
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DOI:
10.3389/fmicb.2020.544490
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发表时间:
2020
影响因子:
5.2
通讯作者:
Drumond MM
Drumond MM
中科院分区:
生物学2区
文献类型:
--
作者:
Batista VL;da Silva TF;de Jesus LCL;Coelho-Rocha ND;Barroso FAL;Tavares LM;Azevedo V;Mancha-Agresti P;Drumond MM

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肠粘膜炎是抗肿瘤药物5-氟尿嘧啶(5-FU)的一种细胞毒性副作用,以溃疡、炎症、腹泻和剧烈腹痛为特征,使其成为临床医学的重要问题。鉴于问题的严重性,已经寻求治疗替代方案作为改善、预防和治疗这种情况的手段。在现有的解决5-FU治疗副作用的替代方案中,最有希望的是使用益生菌、益生菌、合生菌和副益生菌。本文综述了这些“生物制剂”作为治疗5-FU引起的肠粘膜炎的替代疗法的应用。它描述了与使用它们相关的效果和好处,以及它们在病人护理中的潜力。
Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it an important issue for clinical medicine. Given the seriousness of the problem, therapeutic alternatives have been sought as a means to ameliorate, prevent, and treat this condition. Among the alternatives available to address this side effect of treatment with 5-FU, the most promising has been the use of probiotics, prebiotics, synbiotics, and paraprobiotics. This review addresses the administration of these “biotics” as a therapeutic alternative for intestinal mucositis caused by 5-FU. It describes the effects and benefits related to their use as well as their potential for patient care.
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