Immunomodulatory Effects of Probiotics on Cytokine Profiles.
Immunomodulatory Effects of Probiotics on Cytokine Profiles.
复制标题
DOI：
10.1155/2018/8063647
复制
发表时间：
2018
影响因子：
--
通讯作者：
Wan D
中科院分区：
文献类型：
--
作者：
Azad MAK;Sarker M;Wan D
益生菌通过调节、刺激和调节免疫反应来赋予宿主免疫保护作用。研究人员已经将注意力转移到更好地了解益生菌的免疫调节作用，益生菌有可能预防或减轻某些尚未获得适当医疗治疗的病理。已经科学地确定，免疫细胞（T细胞和B细胞）介导适应性免疫，并通过发展病原体特异性记忆来赋予免疫保护。本文就益生菌的免疫调节作用作一综述。在本综述的前一部分，益生菌的概念和常见的益生菌菌株的重点。在优先的基础上，免疫系统，沿着在人体的粘膜免疫，在这项研究中进行了讨论。已经总结了许多种乳酸杆菌和双歧杆菌通过增加自然杀伤细胞的细胞毒性和巨噬细胞的吞噬作用在先天免疫中发挥重要作用，并通过与肠细胞和树突状细胞、Th1、Th2和Treg细胞相互作用介导适应性免疫。最后，本文对益生菌在不同动物模型中对促炎和抗炎细胞因子产生的免疫调节作用进行了广泛的综述。因此，分离新的益生菌菌株并研究其对人类细胞因子谱的免疫调节作用仍然是一个热门问题。
Probiotics confer immunological protection to the host through the regulation, stimulation, and modulation of immune responses. Researchers have shifted their attention to better understand the immunomodulatory effects of probiotics, which have the potential to prevent or alleviate certain pathologies for which proper medical treatment is as yet unavailable. It has been scientifically established that immune cells (T- and B-cells) mediate adaptive immunity and confer immunological protection by developing pathogen-specific memory. However, this review is intended to present the recent studies on immunomodulatory effects of probiotics. In the early section of this review, concepts of probiotics and common probiotic strains are focused on. On a priority basis, the immune system, along with mucosal immunity in the human body, is discussed in this study. It has been summarized that a number of species of Lactobacillus and Bifidobacterium exert vital roles in innate immunity by increasing the cytotoxicity of natural killer cells and phagocytosis of macrophages and mediate adaptive immunity by interacting with enterocytes and dendritic, Th1, Th2, and Treg cells. Finally, immunomodulatory effects of probiotics on proinflammatory and anti-inflammatory cytokine production in different animal models have been extensively reviewed in this paper. Therefore, isolating new probiotic strains and investigating their immunomodulatory effects on cytokine profiles in humans remain a topical issue.
登录
查看更多内容
影响因子：
4.1
作者：
Giorgetti G;Brandimarte G;Fabiocchi F;Ricci S;Flamini P;Sandri G;Trotta MC;Elisei W;Penna A;Lecca PG;Picchio M;Tursi A
通讯作者：
Tursi A
DOI：
10.1016/j.ijfoodmicro.2010.04.007
发表时间：
2010-06-15
影响因子：
5.4
作者：
Foligne, Benoit;Dewulf, Joelle;Pot, Bruno
通讯作者：
Pot, Bruno
影响因子：
4
作者：
Galdeano, CM;Perdigón, G
通讯作者：
Perdigón, G
影响因子：
6.4
作者：
Chiba, Yukihide;Shida, Kan;Nomoto, Koji
通讯作者：
Nomoto, Koji
影响因子：
2.8
作者：
Dogi, C. A.;Weill, F.;Perdigon, G.
通讯作者：
Perdigon, G.