Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease.
Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease.
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DOI：
10.3390/molecules26103011
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发表时间：
2021-05-18
期刊：
影响因子：
--
通讯作者：
Gati A
中科院分区：
文献类型：
--
作者：
ELBini-Dhouib I;Doghri R;Ellefi A;Degrach I;Srairi-Abid N;Gati A
阿尔茨海默病（Alzheimer's disease，AD）是最常见的导致痴呆的神经退行性疾病之一。尽管有研究工作，目前还没有有效的药物治疗方案用于预防和治疗AD。近年来，大量的研究强调了姜黄素（CUR），一种天然多酚，在神经保护中的有益作用。特别是其抗氧化和抗炎的双重特性引起了研究人员的兴趣。事实上，除了其抗氧化和抗炎特性外，这种生物分子在肠道中不会降解。此外，CUR能够穿过血脑屏障，因此可用于治疗与氧化应激、炎症和细胞凋亡相关的神经退行性病变。本研究的目的是评估CUR诱导神经元保护和/或恢复作用的能力，对大鼠模型的神经毒性诱导的氯化铝（AlCl 3），它模仿的散发形式的阿尔茨海默氏病。我们的研究结果表明，治疗与CUR提高促氧化剂水平，抗氧化酶的活性和抗炎细胞因子的产生和减少凋亡细胞在AlCl 3暴露大鼠海马。此外，海马的组织病理学分析揭示了CUR在降低AlCl 3诱导的AD中的标志物方面的潜力。我们还表明，CUR后处理显着改善行为，氧化应激和炎症在AlCl 3暴露大鼠。综上所述，我们的数据表明CUR作为一种营养药物的潜力，通过其保护作用，比在散发性AD模型中的恢复作用更有趣。
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Despite research efforts, currently there are no effective pharmacotherapeutic options for the prevention and treatment of AD. Recently, numerous studies highlighted the beneficial effects of curcumin (CUR), a natural polyphenol, in the neuroprotection. Especially, its dual antioxidant and anti-inflammatory properties attracted the interest of researchers. In fact, besides its antioxidant and anti-inflammatory properties, this biomolecule is not degraded in the intestinal tract. Additionally, CUR is able to cross the blood–brain barrier and could therefore to be used to treat neurodegenerative pathologies associated with oxidative stress, inflammation and apoptosis. The present study aimed to assess the ability of CUR to induce neuronal protective and/or recovery effects on a rat model of neurotoxicity induced by aluminum chloride (AlCl3), which mimics the sporadic form of Alzheimer’s disease. Our results showed that treatment with CUR enhances pro-oxidant levels, antioxidant enzymes activities and anti-inflammatory cytokine production and decreases apoptotic cells in AlCl3-exposed hippocampus rats. Additionally, histopathological analysis of hippocampus revealed the potential of CUR in decreasing the hallmarks in the AlCl3-induced AD. We also showed that CUR post-treatment significantly improved the behavioral, oxidative stress and inflammation in AlCl3-exposed rats. Taken together, our data presented CUR as a nutraceutical potential through its protective effects that are more interesting than recovery ones in sporadic model of AD.
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