African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids.
African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids.
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患有心脏代谢并发症的非洲裔美国妇女的血清丰富性降低了专业的促脂质培养皿和内源性大麻素的血清丰富度。
DOI：
10.3390/nu15010140
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发表时间：
2022-12-28
期刊：
影响因子：
5.9
通讯作者：
Ortlund EA
中科院分区：
文献类型：
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作者：
Maner-Smith KM;Ferranti E;Dunlop A;Corwin E;Ortlund EA
非洲裔美国妇女的孕产妇发病率和死亡率高于其他种族/族裔的美国妇女。妊娠期心脏代谢并发症（包括妊娠期糖尿病、妊娠期高血压和先兆子痫）是孕产妇发病和死亡的主要原因。已知循环脂质的显著变化伴随着妊娠的心脏代谢并发症。血清二十二碳六烯酸（DHA）浓度已被证明与先兆子痫的风险呈负相关。DHA是一类特殊的促溶解介质（SPMs）的生物合成前体，具有抗炎特性，也与妊娠期高血压疾病有关。我们采用靶向脂质组学方法对妊娠早期和晚期（分别为妊娠8-14周和24-30周）收集的母体血清中含dha磷脂和SPMs的分布进行了表征，以确定发生心脏代谢并发症的AA妇女妊娠期间出现失调的关键脂质。我们在AA妇女的妊娠早期血清样本中发现了一个脂质特征，该特征预测妊娠心脏代谢并发症的准确率为74%。这些是Resolvin D1， Resolvin E1, 2-AG， pge2 -甘油酯和36:6 PC。这些发现表明，在妊娠早期可以检测到基于血液的标记物，可以潜在地识别有风险的人，并制定临床干预措施。
African American (AA) women experience higher rates of maternal morbidity and mortality compared to US women of other racial/ ethnic groups. Cardiometabolic complications of pregnancy (including gestational diabetes, gestational hypertension, and preeclampsia) are leading contributors to maternal morbidity and mortality. Marked changes in circulating lipids are known to accompany cardiometabolic complications of pregnancy. Serum concentrations of docosahexaenoic acid (DHA) have been shown to be inversely correlated with risk for preeclampsia. DHA is a biosynthetic precursor of a class of specialized pro-resolving mediators (SPMs), resolvins, that have anti-inflammatory properties and are also associated with hypertensive disorders of pregnancy. We employed targeted lipidomics to characterize the distribution of DHA-containing phospholipids and SPMs in maternal serum collected in early and late pregnancy (8–14 weeks and 24–30 weeks gestation, respectively) to identify key lipids that are dysregulated during pregnancy in AA women who develop cardiometabolic complications. We identified a lipid signature in early pregnancy serum samples of AA women that is predictive of cardiometabolic complications of pregnancy with 74% accuracy. These are Resolvin D1, Resolvin E1, 2-AG, PGE2-glyerol ester, and 36:6 PC. These findings suggest that there are blood-based markers detectable in early pregnancy that can potentially identify persons at risk and tailor clinical interventions.
影响因子：
12.2
作者：
Khan RN;Maner-Smith K;A Owens J;Barbian ME;M Jones R;R Naudin C
通讯作者：
R Naudin C
影响因子：
5.9
作者：
通讯作者：
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