Resolvins' Obesity-Driven Deficiency: The Implications for Maternal-Fetal Health.
Resolvins' Obesity-Driven Deficiency: The Implications for Maternal-Fetal Health.
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由于妊娠在生理条件下已经具有轻微但显著的炎症活动的特征，因此当并发肥胖时，持续性炎症状态的可能性增加，随之而来的多重影响增加了与急性炎症相关的并发症。在这种情况下，消退素的作用，专门的促消退介质（SPM），从ω-3必需脂肪酸衍生，可能是至关重要的。事实上，与分娩和新生儿健康相关的许多高风险条件下的差异生产，母体omega-3摄入量与母体血液和胎盘水平中的消退素浓度之间的相关性，以及母乳喂养第一个月母乳中的高值，是这些autacoids的一些最重要的标志。此外，越来越多的科学证据支持缺乏SPM，在免疫代谢组织的水平上，在肥胖症的情况下。此外，在当前COVID-19爆发的背景下，与肥胖相关的SPM缺乏似乎是决定性的，因为它似乎是与SARS-CoV-2感染的并发症和负面结果发生率较高相关的原因之一。代谢组学在这一领域的有用性似乎很清楚，因为通过代谢组学，可以观察母亲，胎盘和胎儿之间的众多和复杂的相互作用，以确定可用于预测，诊断和监测各种产科条件的特定生物标志物。然而，需要进一步的研究，以评估可能使用的一些resolvins作为母胎结局的生物标志物，但也要建立足够的整合值在孕妇与ω-3脂肪酸或更积极的衍生物，保证最佳的SPM生产在危险的条件下。
Since pregnancy is already characterized by mild but significant inflammatory activity in physiological conditions, when complicated by obesity the probability of a persistent inflammatory state increases, with consequent multiple repercussions that add up to the complications associated with acute inflammation. In this context, the role of resolvins, specialized pro-resolving mediators (SPMs), deriving from omega-3 essential fatty acids, may be crucial. Indeed, differential production in numerous high-risk conditions associated with both childbirth and neonatal health, the correlation between maternal omega-3 intake and resolvin concentrations in maternal blood and at the placental level, and the high values found in breast milk in the first month of breastfeeding, are some of the most important hallmarks of these autacoids. In addition, a growing body of scientific evidence supports the lack of SPMs, at the level of immune-metabolic tissues, in the case of obesity. Furthermore, the obesity-related lack of SPMs seems to be decisive in the context of the current outbreak of COVID-19, as it appears to be one of the causes associated with the higher incidence of complications and negative outcomes of SARS-CoV-2 infection. The usefulness of metabolomics in this field appears clear, given that through the metabolome it is possible to observe the numerous and complex interactions between the mother, the placenta and the fetus in order to identify specific biomarkers useful in the prediction, diagnosis and monitoring of the various obstetric conditions. However, further investigations are needed in order to evaluate the possible use of some resolvins as biomarkers of maternal–fetal outcomes but also to establish adequate integration values in pregnant women with omega-3 fatty acids or with more active derivatives that guarantee optimal SPM production under risky conditions.
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DOI：
10.1016/j.bbalip.2010.08.002
发表时间：
2010-12
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bannenberg G;Serhan CN
通讯作者：
Serhan CN
影响因子：
7.2
作者：
Ghesquière L;Garabedian C;Drumez E;Lemaître M;Cazaubiel M;Bengler C;Vambergue A
通讯作者：
Vambergue A
影响因子：
--
作者：
Fanos V;Atzori L;Makarenko K;Melis GB;Ferrazzi E
通讯作者：
Ferrazzi E
DOI：
10.1016/0002-9378(58)90027-9
发表时间：
1958-01-01
影响因子：
9.8
作者：
GREENBERG, M;JACOBZINER, H;WEISL, BAG
通讯作者：
WEISL, BAG
影响因子：
16.2
作者：
Elias, CF;Aschkenasi, C;Elmquist, JK
通讯作者：
Elmquist, JK