Region-dependent patterns of trabecular bone growth in the human proximal femur: A study of 3D bone microarchitecture from early postnatal to late childhood period.
Region-dependent patterns of trabecular bone growth in the human proximal femur: A study of 3D bone microarchitecture from early postnatal to late childhood period.
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人类股骨近端骨小梁生长的区域依赖性模式：从产后早期到儿童晚期的 3D 骨微结构研究
DOI：
10.1002/ajpa.23268
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发表时间：
2017
影响因子：
2.8
通讯作者：
Djuric M
中科院分区：
文献类型：
--
作者：
Milovanovic P;Djonic D;Hahn M;Amling M;Busse B;Djuric M
目的与身体生长发育平行，非成人的骨骼结构被重组以达到在成熟个体中观察到的特殊设计。我们追踪了运动成熟阶段三维小梁微结构设计的变化，以阐明人类骨骼如何适应机械需求。材料和方法从出生早期到儿童晚期，对股骨近端生物力学相关的亚区（颈部内侧、中间和外侧区域、粗隆间区域、干骺端区域）进行微CT检查。结果骨小梁微结构的发育模式显示，出生时妊娠期产骨过剩在出生后的第一年发生最显著的减少，随后一些定量参数（如骨体积分数、骨小梁各向异性）出现逆转趋势。出生时就已经存在的某些区域各向异性在儿童时期进一步突出，表明对不同负荷环境的适应。股骨颈小梁偏心率在儿童时期尤为突出，这使得内侧颈（主要用于行走的部位）具有优越的微建筑设计（高骨体积分数和各向异性，最早出现并以板状和蜂窝状小梁为主）。在提供骨微结构如何适应运动成熟阶段不断增加的机械需求的定量数据的同时，该研究揭示了股骨近端区域各向异性是如何发展的，以确保功能和胜任的骨结构。分解特定区域的骨量积累模式对于理解骨骼对两足动物的适应，以及理解为什么骨折经常发生在儿童和老年人中，是非常重要的。
ObjectivesParallel with body growth and development, bone structure in non‐adults is reorganized to achieve the particular design observed in mature individuals. We traced the changes in three‐dimensional trabecular microarchitectural design during the phases of locomotor maturation to clarify how human bone adapts to mechanical demands.Materials and MethodsMicro‐CT was performed on biomechanically‐relevant subregions of the proximal femur (medial, intermediate and lateral neck regions, intertrochanteric region, metaphyseal region) from early postnatal period to late childhood.ResultsDevelopmental patterns of trabecular microarchitecture showed that gestationally overproduced bone present at birth underwent the most dramatic reduction during the first year, followed by a reversing trend in some of the quantitative parameters (e.g., bone volume fraction, trabecular anisotropy). Certain regional anisotropy already present at birth is further accentuated into the childhood suggesting an adaptation to differential loading environments. Trabecular eccentricity in the femoral neck was particularly accentuated during childhood, giving the medial neck—the site mostly loaded in walking—superior microarchitectural design (high bone volume fraction and anisotropy, the earliest appearance and predominance of plate‐ and honeycomb‐shaped trabeculae).DiscussionWhile providing quantitative data on how bone microarchitecture adapts to increasing mechanical demands occurring during the phases of locomotor maturation, the study reveals how regional anisotropy develops in the proximal femur to ensure a functional and competent bone structure. Decomposing the region‐specific patterns of bone mass accrual is important in understanding skeletal adaptations to bipedalism, as well for understanding why fractures often occur location‐dependent, both in pediatric and elderly individuals.
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DOI：
10.1016/s0166-4115(08)60959-0
发表时间：
1993
期刊：
Advances in psychology
影响因子：
--
作者：
B. Bril;Y. Brenière
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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通讯作者：
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影响因子：
4.1
作者：
Verhulp, E.;van Rietbergen, B.;Huiskes, R.
通讯作者：
Huiskes, R.