Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis.
Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis.
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DOI：
10.3390/molecules26010031
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发表时间：
2020-12-23
期刊：
影响因子：
--
通讯作者：
Yang GY
中科院分区：
文献类型：
--
作者：
Weinberg SE;Sun LY;Yang AL;Liao J;Yang GY
慢性炎症是人类癌症（包括结肠癌）最常见和公认的风险因素之一。炎症性肠病（IBD）是指结肠长期存在的特发性慢性活动性炎症过程，包括溃疡性结肠炎和克罗恩病。重要的是，IBD患者发生结直肠癌的风险显著增加。众所周知，膳食肌醇及其磷酸盐以及磷脂衍生物在包括癌症预防在内的多种病理学中有益于人类健康。肌醇磷酸（包括InsP3、InsP6和其他焦磷酸）在参与控制细胞增殖、分化、RNA输出、DNA修复、能量转导、ATP再生等的细胞代谢和信号转导途径中起重要作用。在综述中，我们强调了肌醇及其磷酸盐的生物功能和健康效应，包括这些分子的性质和来源，潜在的营养缺乏，它们的生物代谢和功能，最后，它们在预防结肠炎诱发的致癌作用。
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn’s disease. Importantly, patients with IBD have a significantly increased risk for the development of colorectal carcinoma. Dietary inositol and its phosphates, as well as phospholipid derivatives, are well known to benefit human health in diverse pathologies including cancer prevention. Inositol phosphates including InsP3, InsP6, and other pyrophosphates, play important roles in cellular metabolic and signal transduction pathways involved in the control of cell proliferation, differentiation, RNA export, DNA repair, energy transduction, ATP regeneration, and numerous others. In the review, we highlight the biologic function and health effects of inositol and its phosphates including the nature and sources of these molecules, potential nutritional deficiencies, their biologic metabolism and function, and finally, their role in the prevention of colitis-induced carcinogenesis.
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影响因子：
7.3
作者：
Chakraborty A;Kim S;Snyder SH
通讯作者：
Snyder SH
DOI：
10.1016/j.jchromb.2012.01.035
发表时间：
2012-04-15
影响因子：
3
作者：
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影响因子：
14.9
作者：
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影响因子：
7.7
作者：
CLEMENTS, RS;REYNERTSON, R
通讯作者：
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影响因子：
6.1
作者：
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通讯作者：
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