Risk factors for previously undiagnosed primary open-angle glaucoma: the EPIC-Norfolk Eye Study.
Risk factors for previously undiagnosed primary open-angle glaucoma: the EPIC-Norfolk Eye Study.
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未确诊的原发性开角型青光眼的危险因素：EPIC-Norfolk眼科研究
DOI：
10.1136/bjophthalmol-2020-317718
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发表时间：
2022-12
影响因子：
4.1
通讯作者：
Foster, Paul J.
中科院分区：
文献类型：
--
作者：
Chan, Michelle P. Y.;Khawaja, Anthony P.;Broadway, David C.;Yip, Jennifer;Luben, Robert;Hayat, Shabina;Peto, Tunde;Khaw, Kay-Tee;Foster, Paul J.
关键词：
未确诊的青光眼是一个无形但重要的公共卫生问题。据估计，在西方人群中，至少有一半的青光眼病例未被诊断。本研究的目的是检查以前未确诊的原发性开角型青光眼（POAG）的危险因素。欧洲癌症前瞻性研究-诺福克眼科研究中的横断面研究，这是一项在英国进行的大规模队列研究。314名研究参与者的任一只眼患有POAG。Logistic回归分析与既往未诊断的POAG和既往诊断的POAG的相关性。检查的因素包括社会人口统计学、眼部、身体和经济因素，这些因素可能是获得眼科护理的障碍。217名参与者先前诊断为POAG，107名参与者在研究期间新诊断为POAG。校正协变量后，与既往未诊断POAG显著相关的因素为：治疗前较低的眼内压（IOP）（OR 0.71/mm Hg，95% CI 0.63 - 0.80，p<0.0001），以及报告视力无问题（OR 0.03，95% CI 0.01 - 0.10，p<0.0001）。本研究中确定的既往未确诊的POAG的风险因素强调了青光眼筛查中对IOP水平的过度依赖以及低IOP病例中青光眼漏诊的风险。它还表明了在提高社区青光眼意识方面的作用。
Undiagnosed glaucoma is an invisible but important public health issue. At least half of glaucoma cases are estimated to be undiagnosed in western populations. The aim of this study is to examine risk factors for previously undiagnosed primary open-angle glaucoma (POAG). Cross-sectional study within the European Prospective Investigation of Cancer-Norfolk Eye Study, a large-scale cohort study in the UK. 314 study participants with POAG in either eye. Logistic regression was used to examine associations with previously undiagnosed POAG compared with previously diagnosed POAG. The factors examined included sociodemographic, ocular, physical and economic factors that could be barriers to eye care access. 217 participants had previously diagnosed POAG and 107 participants were newly diagnosed with POAG during the study. After adjusting for covariables, the factors significantly associated with previously undiagnosed POAG were: a lower pretreatment intraocular pressure (IOP) (OR 0.71/mm Hg, 95% CI 0.63 to 0.80, p<0.0001), and to have reported no problems with their eyesight (OR 0.03, 95% CI 0.01 to 0.10, p<0.0001). The risk factors for previously undiagnosed POAG identified in this study highlight the over-reliance on IOP level in glaucoma screening and the risk of missing glaucoma among lower IOP cases. It also suggests a role in improving glaucoma awareness in the community.
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影响因子：
4.2
作者：
Topouzis, Fotis;Coleman, Anne L.;Wilson, M. Roy
通讯作者：
Wilson, M. Roy
影响因子：
13.7
作者：
Wong, EYH;Keeffe, JE;Taylor, HR
通讯作者：
Taylor, HR
影响因子：
13.7
作者：
Hennis, Anselm;Wu, Suh-Yuh;Leske, M. Cristina
通讯作者：
Leske, M. Cristina
影响因子：
13.7
作者：
Mitchell, P;Smith, W;Healey, PR
通讯作者：
Healey, PR
DOI：
10.1136/bmj.j3889
发表时间：
2017-09-13
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Chan MPY;Broadway DC;Khawaja AP;Yip JLY;Garway-Heath DF;Burr JM;Luben R;Hayat S;Dalzell N;Khaw KT;Foster PJ
通讯作者：
Foster PJ