Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study.
Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study.
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DOI：
10.1136/bmj.j3889
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发表时间：
2017-09-13
期刊：
影响因子：
--
通讯作者：
Foster PJ
中科院分区：
文献类型：
--
作者：
Chan MPY;Broadway DC;Khawaja AP;Yip JLY;Garway-Heath DF;Burr JM;Luben R;Hayat S;Dalzell N;Khaw KT;Foster PJ
目的报告不同年龄、性别的眼内压（IOP）分布以及青光眼的患病率。 设计基于社区的横断面观察性研究。 设置EPIC-诺福克队列在诺维奇和周围的农村和城市地区。 参与者8623名年龄在48-92岁之间的参与者从社区招募，他们接受了眼科检查以识别青光眼。 主要观察指标：青光眼的患病率和特征，眼压分布，眼压对青光眼病例发现的敏感性和特异性。 结果8401例受试者的平均眼压为16.3 mm Hg（95%置信区间为16.2 mm Hg至16.3 mm Hg; SD为3.6 mm Hg）。在363名参与者（4%）中，青光眼存在于任何一只眼睛中; 314名（87%）患有原发性开角型青光眼。在其余的参与者中，607人（7%）疑似青光眼，863人（10.0%）患有高眼压。三分之二（242）的青光眼患者以前已经接受过诊断。在76%的新诊断原发性开角型青光眼患者（83/107）中，平均IOP低于高眼压阈值（21 mm Hg）。没有一个眼压阈值提供足够高的敏感性和特异性青光眼的诊断。 结论在英国社区，青光眼、疑似青光眼和高眼压的病例代表了大量潜在的转诊到医院眼科服务的病例。使用IOP检测青光眼是不准确的，可能也不可行。
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma. Design Community based cross sectional observational study. Setting EPIC-Norfolk cohort in Norwich and the surrounding rural and urban areas. Participants 8623 participants aged 48-92 recruited from the community who underwent ocular examination to identify glaucoma. Main outcome measures Prevalence and characteristics of glaucoma, distribution of IOP, and the sensitivity and specificity of IOP for case finding for glaucoma. Results The mean IOP in 8401 participants was 16.3 mm Hg (95% confidence interval 16.2 mm Hg to 16.3 mm Hg; SD 3.6 mm Hg). In 363 participants (4%), glaucoma was present in either eye; 314 (87%) had primary open angle glaucoma. In the remaining participants, glaucoma was suspected in 607 (7%), and 863 (10.0%) had ocular hypertension. Two thirds (242) of those with glaucoma had previously already received the diagnosis. In 76% of patients with newly diagnosed primary open angle glaucoma (83/107), the mean IOP was under the threshold for ocular hypertension (21 mm Hg). No one IOP threshold provided adequately high sensitivity and specificity for diagnosis of glaucoma. Conclusions In this British community, cases of glaucoma, suspected glaucoma, and ocular hypertension represent a large number of potential referrals to the hospital eye service. The use of IOP for detection of those with glaucoma is inaccurate and probably not viable.
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影响因子：
--
作者：
LESKE, MC;CONNELL, AMS;HYMAN, L
通讯作者：
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影响因子：
2.9
作者：
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影响因子：
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通讯作者：
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影响因子：
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