Obesity is associated with copper elevation in serum and tissues.
Obesity is associated with copper elevation in serum and tissues.
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DOI：
10.1039/c9mt00148d
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发表时间：
2019-08-01
期刊：
影响因子：
--
通讯作者：
Lutsenko S
中科院分区：
文献类型：
--
作者：
Yang H;Liu CN;Wolf RM;Ralle M;Dev S;Pierson H;Askin F;Steele KE;Magnuson TH;Schweitzer MA;Wong GW;Lutsenko S
铜失衡与动物和实验系统中的脂肪积累有关;然而，关于人类肥胖中铜稳态的信息有限。在这项研究中，通过测量血清、脂肪和肝组织中铜和铜蛋白的水平来评估肥胖个体的铜状况。在控制性别、年龄和种族后，血清微量元素分析显示铜与BMI之间存在显著的正相关和元素特异性相关。血清铜与瘦素、胰岛素及瘦素/BMI比值呈正相关。与瘦对照组相比，肥胖患者的循环铜蛋白升高，如semucarbazide敏感胺氧化酶（SSAO）和铜蓝蛋白，SSAO活性和内脏脂肪中的铜水平更高。虽然肝脂肪变性会降低肝脏中的铜水平，但与瘦对照组相比，没有或轻度脂肪变性的肥胖患者肝脏中的铜含量较高。总之，在这项研究中评估的肥胖患者改变了铜状态。铜水平与BMI和瘦素的强正相关性表明，铜和/或铜蛋白可能在功能上与脂肪积累有关。
Copper misbalance has been linked to fat accumulation in animals and experimental systems; however, information about copper homeostasis in human obesity is limited. In this study, the copper status of obese individuals was evaluated by measuring their levels of copper and cuproproteins in serum, adipose and hepatic tissues. The analysis of serum trace elements showed significant positive and element-specific correlation between copper and BMI after controlling for gender, age, and ethnicity. Serum copper also positively correlated with leptin, insulin, and the leptin/BMI ratio. When compared to lean controls, obese patients had elevated circulating cuproproteins, such as semucarbazide-sensitive amine oxidase (SSAO) and ceruloplasmin, and higher SSAO activity and copper levels in visceral fat. Although hepatic steatosis reduces copper levels in the liver, obese patients with no or mild steatosis have higher copper content in the liver compared to lean controls. In conclusion, obese patients evaluated in this study had altered copper status. Strong positive correlations of copper levels with BMI and leptin suggest that copper and/or cuproproteins may be functionally linked to fat accumulation.
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影响因子：
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作者：
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