Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles.
Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles.
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药物自组装用于合成高载的抗菌药物硅颗粒。
DOI：
10.1038/s41598-018-19166-8
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发表时间：
2018-01-17
影响因子：
4.6
通讯作者：
Hatton BD
中科院分区：
文献类型：
--
作者：
Stewart CA;Finer Y;Hatton BD
从用于骨科修复和牙科修复的生物材料中释放抗菌药物可以防止生物膜生长和龋齿形成。用于药物掺入的载体将受益于长期药物储存、控制释放和结构稳定性。通过二氧化硅和表面活性剂模板的共组装合成的介孔二氧化硅是理想的药物包封支架，其在释放时保持结构完整性。然而，通过浓度梯度扩散在介孔二氧化硅孔内的常规药物负载限制了总体有效载荷、浓度均匀性和药物释放控制。在本文中，我们证明了抗微生物药物（奥替尼啶二盐酸盐，OCT）和二氧化硅的共组装，以形成高负载（35%wt.）直径为500 nm的OCT-二氧化硅纳米复合材料球体。药物释放显着超过传统的OCT负载介孔二氧化硅，密切配合Higuchi模型的扩散释放，并通过电子显微镜可视化。将这一概念扩展到广泛的自组装药物，为生物医学界提供了一个自下而上合成载药无机纳米材料的有力工具。
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control. Herein we demonstrate the co-assembly of an antimicrobial drug (octenidine dihydrochloride, OCT), and silica, to form highly-loaded (35% wt.) OCT-silica nanocomposite spheres of 500 nm diameter. Drug release significantly outlasted conventional OCT-loaded mesoporous silica, closely fit Higuchi models of diffusive release, and was visualized via electron microscopy. Extension of this concept to the broad collection of self-assembling drugs grants biomedical community a powerful tool for synthesizing drug-loaded inorganic nanomaterials from the bottom-up.
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影响因子：
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作者：
Hou, June Chunqiu;Min, Le;Pessin, Jeffrey E.
通讯作者：
Pessin, Jeffrey E.
影响因子：
9.5
作者：
Ganesh, Ahil N.;McLaughlin, Christoiher K.;Shoichet, Molly S.
通讯作者：
Shoichet, Molly S.
影响因子：
8.6
作者：
Argyo, Christian;Weiss, Veronika;Bein, Thomas
通讯作者：
Bein, Thomas
影响因子：
8.6
作者：
Fontecave, Thomas;Boissiere, Cedric;Sanchez, Clement
通讯作者：
Sanchez, Clement
影响因子：
8.6
作者：
Fontecave, Thomas;Sanchez, Clement;Boissiere, Cedric
通讯作者：
Boissiere, Cedric