Total body fat and the risk of Barrett's oesophagus - a bioelectrical impedance study.
Total body fat and the risk of Barrett's oesophagus - a bioelectrical impedance study.
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DOI：
10.1016/j.canep.2014.03.006
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发表时间：
2014-06
影响因子：
2.6
通讯作者：
Whiteman, David C.
中科院分区：
文献类型：
--
作者：
Kendall, Bradley J.;Macdonald, Graeme A.;Prins, Johannes B.;O'Brien, Suzanne;Whiteman, David C.
体重指数与巴雷特食道(BO)的风险有关。目前还不确定这是否与身体总脂肪或其他与体重指数相关的因素有关。我们的目的是量化全身脂肪(通过生物电阻抗测量)和BO风险之间的联系，并检查这种联系是否被胃食道反流(GOR)和腹型肥胖所改变。在2007-2009年，我们调查了235例(男性占69%，平均年龄62.1岁)和244例年龄和性别匹配的人群对照病例，这些病例来自一项基于人群的BO病例对照研究。我们进行了结构化访谈、标准人体测量和全身脂肪的生物阻抗分析。多变量Logistic回归分析估计优势比(OR)和95%可信区间(CI)。总体脂肪重量(OR 2.01；95%CI 1.26~3.21)和总体脂肪百分比(OR 1.86；95%CI 1.10~3.15)最高的人群发生BO的风险显著增加。在调整了GOR和腰围后，这些风险在很大程度上得到了减弱。腰围最高三分位数(OR 2.21；95%可信区间1.39-3.51)的人群发生BO的风险显著增加，经总体脂调整后，BO风险最小，经GOR调整后，BO风险适度降低。全身脂肪与BO风险增加有关，但这似乎是通过腹型肥胖和GOR来调节的。这些发现提供了证据，即腹型肥胖在BO的发生发展中比全身脂肪更重要。
Body mass index is associated with the risk of Barrett's oesophagus (BO). It is uncertain whether this is related to total body fat or other factors that correlate with body mass index. We aimed to quantify the association between total body fat (measured by bioelectrical impedance) and risk of BO and examine if this association was modified by gastro-oesophageal reflux (GOR) and abdominal obesity. In 2007-9, we surveyed 235 cases (69% Males, Mean age 62.1 years) and 244 age and sex matched population controls from a population based case-control study of BO. We conducted structured interviews, standard anthropometry and bioimpedance analysis of total body fat. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression analysis. There was a significantly increased risk of BO among those in the highest tertile of total body fat weight (OR 2.01; 95%CI 1.26-3.21) and total body fat percentage (OR 1.86; 95%CI 1.10-3.15). These risks were largely attenuated after adjustment for GOR and waist circumference. There was a significantly increased risk of BO among those in the highest tertile of waist circumference (OR 2.21; 95%CI 1.39-3.51) and this was minimally attenuated after adjustment for total body fat and moderately attenuated after adjustment for GOR. Total body fat is associated with an increased risk of BO but this appears to be mediated via both abdominal obesity and GOR. These findings provide evidence that abdominal obesity is more important than total body fat in the development of BO.
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影响因子：
6.9
作者：
Nyholm, Maria;Gullberg, Bo;Lindblad, Ulf
通讯作者：
Lindblad, Ulf
影响因子：
24.5
作者：
Whiteman, D. C.;Sadeghi, S.;Green, A. C.
通讯作者：
Green, A. C.
影响因子：
24.5
作者：
Jacobson BC;Chan AT;Giovannucci EL;Fuchs CS
通讯作者：
Fuchs CS
影响因子：
7.1
作者：
LUKASKI, HC;JOHNSON, PE;LYKKEN, GI
通讯作者：
LYKKEN, GI
影响因子：
6.4
作者：
MacInnis, RJ;English, DR;Giles, GG
通讯作者：
Giles, GG