Extended Targeted and Non-Targeted Strategies for the Analysis of Marine Toxins in Mussels and Oysters by (LC-HRMS).
Extended Targeted and Non-Targeted Strategies for the Analysis of Marine Toxins in Mussels and Oysters by (LC-HRMS).
复制标题
通过（LC-HRMS）在贻贝和牡蛎中分析海洋毒素的扩展目标和非目标策略。
DOI：
10.3390/toxins10090375
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发表时间：
2018-09-14
期刊：
影响因子：
4.2
通讯作者：
Guérin T
中科院分区：
文献类型：
--
作者：
Dom I;Biré R;Hort V;Lavison-Bompard G;Nicolas M;Guérin T
When considering the geographical expansion of marine toxins, the emergence of new toxins and the associated risk for human health, there is urgent need for versatile and efficient analytical methods that are able to detect a range, as wide as possible, of known or emerging toxins. Current detection methods for marine toxins rely on a priori defined target lists of toxins and are generally inappropriate for the detection and identification of emerging compounds. The authors describe the implementation of a recent approach for the non-targeted analysis of marine toxins in shellfish with a focus on a comprehensive workflow for the acquisition and treatment of the data generated after liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) analysis. First, the study was carried out in targeted mode to assess the performance of the method for known toxins with an extended range of polarities, including lipophilic toxins (okadaic acid, dinophysistoxins, azaspiracids, pectenotoxins, yessotoxins, cyclic imines, brevetoxins) and domoic acid. The targeted method, assessed for 14 toxins, shows good performance both in mussel and oyster extracts. The non-target potential of the method was then challenged via suspects and without a priori screening by blind analyzing mussel and oyster samples spiked with marine toxins. The data processing was optimized and successfully identified the toxins that were spiked in the blind samples.
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影响因子：
4.3
作者：
Gerssen, Arjen;van Olst, Erik H. W.;Mulder, Patrick P. J.;de Boer, Jacob
通讯作者：
de Boer, Jacob
影响因子：
7.4
作者：
Gerssen, Arjen;van den Top, Hester J.;van Egmond, Hans P.
通讯作者：
van Egmond, Hans P.
影响因子：
1.6
作者：
McCarron, Pearse;Wright, Elliott;Quilliam, Michael A.
通讯作者：
Quilliam, Michael A.
影响因子：
2.8
作者：
James, KJ;Gillman, M;Furey, A
通讯作者：
Furey, A
影响因子：
4.1
作者：
Domenech, Albert;Cortes-Francisco, Nuria;Caixach, Josep
通讯作者：
Caixach, Josep