Music intervention improves spatial learning and memory and alters serum proteomics profiling in rats
Music intervention improves spatial learning and memory and alters serum proteomics profiling in rats
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音乐干预可改善大鼠的空间学习和记忆并改变血清蛋白质组学分析
DOI：
10.1002/jnr.24275
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Chen Huang
中科院分区：
文献类型：
--
作者：
Xiaofan Xiong;Lin Han;Siyuan Liu;Jiyu Miao;Mai Luo;Meng Xue;Xiaofei Wang;Lei Ni;Juan Yang;Chen Huang
音乐在临床治疗或减轻身心疾病方面有着悠久的历史。我们的目的是测试大鼠接受音乐干预（MI）的行为认知和血清蛋白质组学的变化。采用Morris水迷宫（MWM）评价大鼠的空间学习记忆能力。使用基于磁珠的基质辅助激光解吸/电离飞行时间（MALDI-TOF-MS）检查血清蛋白表达谱。MI改善雄性和雌性大鼠的空间学习和记忆。与对照组雌性动物相比，MI雌性动物的峰1708.61（m/z值）显著增加。与雄性对照组相比，MI雄性中的峰3925.09（m/z值）显著降低。两个差异血清肽峰（m/z值：1708.61，3925.09）被进一步序列鉴定为蛋白Desmin和Acsm 1的区域。结蛋白表达的Western印迹和免疫荧光检测显示蛋白质组学分析的一致结果。MI在大鼠的行为认知和蛋白表达中起重要作用。这项研究为MI可能改善空间学习和记忆能力提供了蛋白质组学基础。
Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein expression profiling was examined using magnetic bead‐based matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF‐MS). MI improved spatial learning and memory in both male and female rats. Peak 1708.61 (m/z values) was significantly increased in MI females vs. female controls. Peak 3925.09 (m/z values) was significantly reduced in MI males versus male controls. The two differential serum peptide peaks (m/z values: 1708.61, 3925.09) were further sequence identified as regions of proteins Desmin and Acsm1. Western blot and immunofluorescence testing of Desmin expression showed consistent results on proteomics analysis. MI plays an important role in behavioral cognition and protein expression in rats. This study provides a foundation in proteomics that suggests that MI might improve spatial learning and memory ability.
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影响因子：
--
作者：
Wada, Nobuhiro;Yamanaka, Satoru;Shibato, Junko;Rakwal, Randeep;Hirako, Satoshi;Iizuka, Yuzuru;Kim, Hyounju;Matsumoto, Akiyo;Kimura, Ai;Takenoya, Fumiko;Yasunaga, Genta;Shioda, Seiji
通讯作者：
Shioda, Seiji
影响因子：
6.4
作者：
T. Sugimoto;H. Ueyama;H. Hosoi;J. Inazawa;Taiji Kato;J. Kemshead;C. Reynolds;A. Gown;H. Mine;T. Sawada
通讯作者：
T. Sugimoto;H. Ueyama;H. Hosoi;J. Inazawa;Taiji Kato;J. Kemshead;C. Reynolds;A. Gown;H. Mine;T. Sawada
影响因子：
12.7
作者：
Winter L;Wittig I;Peeva V;Eggers B;Heidler J;Chevessier F;Kley RA;Barkovits K;Strecker V;Berwanger C;Herrmann H;Marcus K;Kornblum C;Kunz WS;Schröder R;Clemen CS
通讯作者：
Clemen CS
影响因子：
2
作者：
Palmiero, Massimiliano;Nori, Raffaella;Piccardi, Laura
通讯作者：
Piccardi, Laura
DOI：
--
发表时间：
2005-08
期刊：
Zhongguo zhen jiu = Chinese acupuncture & moxibustion
影响因子：
--
作者：
Jin Zhang;Yi-hong Zhang;Yan-Jie Bai
通讯作者：
Jin Zhang;Yi-hong Zhang;Yan-Jie Bai