Validation of a latent variable representing the dementing process.
Validation of a latent variable representing the dementing process.
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验证代表痴呆过程的潜在变量。
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
S. O'Bryant
中科院分区：
文献类型：
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作者：
D. Royall;R. Palmer;S. O'Bryant
功能状态的认知相关性对于发现痴呆病例至关重要。然而，认知表现通常是功能预后的弱预测因子。我们使用结构方程模型来明确区分功能状态，因此认知任务表现中的“痴呆症相关”方差（即δ）与与痴呆过程无关的方差（即g'）。总的来说，g′+ δ包含了斯皮尔曼的g。虽然δ只代表了认知任务表现总方差的一小部分，但它与痴呆状态的关系比g′更密切。在这项研究中，我们在一个特征明确的阿尔茨海默病队列——德克萨斯阿尔茨海默病研究与护理联盟中验证了δ。我们的方法产生了“无误差”的连续变量。这表明δ可以作为痴呆特异性的内表型。因此，未来的研究可能能够将δ与炎症和遗传生物标志物联系起来。
The cognitive correlates of functional status are essential to dementia case-finding. Nevertheless, cognitive performance is a generally weak predictor of functional outcomes. We have employed structural equation models to explicitly distinguish functional status, and therefore "dementia-relevant" variance in cognitive task performance (i.e., δ) from the variance that is unrelated to a dementing process (i.e., g'). Together, g' + δ encompass Spearman's g. Although δ represents only a small fraction of the total variance in cognitive task performance, it is more strongly associated with dementia status than is g'. In this study, we validate δ in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. Our approach results in "error free" continuous variables. This suggests that δ can serve as a dementia specific endophenotype. As a result, future studies may be able to associate δ with inflammatory and genetic biomarkers.
影响因子：
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作者：
O'Bryant, Sid E.;Waring, Stephen C.;Cullum, C. Munro;Hall, James;Lacritz, Laura;Massman, Paul J.;Lupo, Philip J.;Reisch, Joan S.;Doody, Rachelle
通讯作者：
Doody, Rachelle
影响因子：
7.2
作者：
Jefferson, Angela L.;Byerly, Laura K.;Karlawish, Jason H.
通讯作者：
Karlawish, Jason H.