Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity.
Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity.
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DOI：
10.1186/ar3513
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发表时间：
2011
影响因子：
4.9
通讯作者：
Martinez-Lavin M
中科院分区：
文献类型：
--
作者：
Lerma C;Martinez A;Ruiz N;Vargas A;Infante O;Martinez-Lavin M
目前，既没有实验室测试也没有成像技术能够区分纤维肌痛 (FM) 患者与健康对照者。缺乏客观的生物标志物阻碍了 FM 的识别和研究。心率变异性 (HRV) 分析提供自主神经系统活动的定量标记。夜间是大多数人休息的稳定时期。睡眠是由自主活动调节的。睡眠问题在FM中尤为突出。本研究的目的是：1) 探索不同的夜间 HRV 参数作为潜在的 FM 生物标志物，2) 寻求此类 HRV 参数与不同 FM 症状之间的相关性。我们研究了 22 名患有 FM 的女性和 22 名年龄匹配的对照组。所有参与者都填写了几份与 FM 症状相关的调查问卷。所有参与者在白天进行日常活动和晚上在家睡觉时都使用动态心电图监测仪超过 24 小时。从 0000 到 0600 小时分析的时域 HRV 参数包括：平均正常-正常心跳间隔 (mean NN)、NN 间隔的标准偏差 (SDNN) 和连续 NN 差异的标准偏差 (SDSD)。小于 114 毫秒的夜间 SDNN 具有最大的预测价值，可将患者与对照组区分开来，比值比为 13.6（95% 置信区间：3.9 至 47.8）。在患者中，表明交感神经优势的夜间 HRV 标记物减少与几种 FM 症状显着相关：SDSD 与疼痛强度相关（r = - 0.65，P = 0.001）。 SDNN 与便秘相关（r = - 0.53，P = 0.001），平均 NN 与抑郁相关（r = - 0.53，P = 0.001）。控件表现出相反的行为。对于他们来说，夜间 SDNN 增加与纤维肌痛影响问卷评分（r = 0.69，P = 0.001）和其他 FM 症状相关。与健康个体相比，FM 女性的夜间 HRV 指数（表明交感优势）存在显着差异。在 FM 患者中，这些 HRV 参数与包括疼痛严重程度在内的多种症状相关。在对照中观察到相反的关联。 FM 可能不仅仅是一系列连续常见症状的一端。夜间 HRV 分析是潜在的 FM 生物标志物。
At present, there is neither a laboratory test nor an imaging technique able to differentiate people with fibromyalgia (FM) from healthy controls. This lack of an objective biomarker has hampered FM recognition and research. Heart rate variability (HRV) analyses provide a quantitative marker of autonomic nervous system activity. Nighttime is a stable period in which most people are resting. Sleep is modulated by autonomic activity. Sleeping problems are prominent in FM. The objectives of this study are: 1) to explore different nocturnal HRV parameters as potential FM biomarkers and 2) to seek correlation between such HRV parameters and diverse FM symptoms. We studied 22 women suffering from FM and 22 age-matched controls. All participants filled out several questionnaires related to FM symptoms. All participants used a Holter monitor over 24 hours while undertaking their routine activities during the day and while sleeping at their homes at night. Time-domain HRV parameters analyzed from 0000 to 0600 hours included, among others: mean normal-normal interbeat intervals (mean NN), standard deviation of the NN intervals (SDNN), and standard deviation of the successive NN differences (SDSD). Nocturnal SDNN of less than 114 ms had the greatest predictive value to set apart patients from controls with an odds ratio of 13.6 (95% confidence interval: 3.9 to 47.8). In patients, decreased nighttime HRV markers indicative of sympathetic predominance had significant correlations with several FM symptoms: SDSD was associated with pain intensity (r = - 0.65, P = 0.001). SDNN correlated with constipation (r = - 0.53, P = 0.001), and mean NN with depression (r = - 0.53, P = 0.001). Controls displayed an opposite behavior. For them, increased nighttime SDNN correlated with Fibromyalgia Impact Questionnaire scores (r = 0.69, P = 0.001) and with other FM symptoms. Nocturnal HRV indices indicative of sympathetic predominance are significantly different in FM women when compared to healthy individuals. In FM patients, these HRV parameters correlated with several symptoms including pain severity. Opposite associations were seen in controls. FM may not be just one end of a continuous spectrum of common symptoms. Nocturnal HRV analyses are potential FM biomarkers.
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影响因子：
27.4
作者：
Croft, P;Burt, J;Silman, A
通讯作者：
Silman, A
DOI：
10.3899/jrheum.090051
发表时间：
2009-09
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Chervin RD;Teodorescu M;Kushwaha R;Deline AM;Brucksch CB;Ribbens-Grimm C;Ruzicka DL;Stein PK;Clauw DJ;Crofford LJ
通讯作者：
Crofford LJ
影响因子：
4.9
作者：
Vargas-Alarcón G;Fragoso JM;Cruz-Robles D;Vargas A;Vargas A;Lao-Villadóniga JI;García-Fructuoso F;Ramos-Kuri M;Hernández F;Springall R;Bojalil R;Vallejo M;Martínez-Lavín M
通讯作者：
Martínez-Lavín M
影响因子：
--
作者：
Vargas-Alarcon, Gilberto;Fragoso, Jose-Manuel;Martinez-Lavin, Manuel
通讯作者：
Martinez-Lavin, Manuel
影响因子：
2.3
作者：
Martinez-Lavin, M;Vidal, M;Nava, A
通讯作者：
Nava, A